TY - CHAP
T1 - Assessing risk of bias and applicability
AU - Reitsma, Johannes B.
AU - Rutjes, Anne W.
AU - Whiting, Penny
AU - Yang, Bada
AU - Leeflang, Mariska M.
AU - Bossuyt, Patrick M.
AU - Deeks, Jonathan J.
N1 - Publisher Copyright: © 2023 The Cochrane Collaboration. Published 2023 by John Wiley & Sons Ltd.
PY - 2023/6/16
Y1 - 2023/6/16
N2 - The findings of the assessment of risk of bias and applicability play an important role in the systematic review process, in particular in the analysis and interpretation of results. This chapter focuses on assessing risk of bias and applicability for individual studies in a review. It also provides guidance on assessing comparative accuracy studies. A large number of methodological quality assessment tools are available for test accuracy studies. Because of the lack of a universal tool that can be used for test accuracy studies across all clinical domains and types of index tests, an initiative was started to develop a generic tool named QUADAS. QUADAS-2 is a revision of the original QUADAS tool. QUADAS-2 assesses the risk of bias of a study across four domains: participant selection, index test, reference standard, and flow and timing, as well as an overall assessment of risk of bias.
AB - The findings of the assessment of risk of bias and applicability play an important role in the systematic review process, in particular in the analysis and interpretation of results. This chapter focuses on assessing risk of bias and applicability for individual studies in a review. It also provides guidance on assessing comparative accuracy studies. A large number of methodological quality assessment tools are available for test accuracy studies. Because of the lack of a universal tool that can be used for test accuracy studies across all clinical domains and types of index tests, an initiative was started to develop a generic tool named QUADAS. QUADAS-2 is a revision of the original QUADAS tool. QUADAS-2 assesses the risk of bias of a study across four domains: participant selection, index test, reference standard, and flow and timing, as well as an overall assessment of risk of bias.
KW - Applicability judgements
KW - Comparative accuracy studies
KW - Index test
KW - Participant selection
KW - QUADAS-2 tool
KW - Quality assessment tools
KW - Reference standard
KW - Risk of bias
KW - Test accuracy studies
UR - http://www.scopus.com/inward/record.url?scp=85168371994&partnerID=8YFLogxK
U2 - https://doi.org/10.1002/9781119756194.ch8
DO - https://doi.org/10.1002/9781119756194.ch8
M3 - Chapter
SN - 9781119756163
T3 - Cochrane Handbook for Systematic Reviews of Diagnostic Test Accuracy
SP - 169
EP - 201
BT - Cochrane Handbook for Systematic Reviews of Diagnostic Test Accuracy
PB - John Wiley and Sons Ltd.
ER -