TY - JOUR
T1 - Assessment of liver function by gadoxetic acid avidity in MRI in a model of rapid liver regeneration in rats
AU - Heil, Jan
AU - Augath, Mark
AU - Kurtcuoglu, Vartan
AU - Hohmann, Joachim
AU - Bechstein, Wolf O.
AU - Olthof, Pim
AU - Schnitzbauer, Andreas A.
AU - Seebeck, Petra
AU - Schiesser, Marc
AU - Schläpfer, Martin
AU - Beck-Schimmer, Beatrice
AU - Schadde, Erik
N1 - Funding Information: This work was supported by the Deutsche Forschungsgemeinschaft, Bonn, Germany , grant no. 423392184 by funding the postdoctoral fellowship (JH), by the Swiss National Science Foundation , grant no. 310030_179247 (BBS) as well as by the Swiss National Science Foundation , grant no. 316030_183528 (BBS) for the purchase of the MRI. Publisher Copyright: © 2023
PY - 2024/4
Y1 - 2024/4
N2 - Background: This animal study investigates the hypothesis of an immature liver growth following ALPPS (associating liver partition and portal vein ligation for staged hepatectomy) by measuring liver volume and function using gadoxetic acid avidity in magnetic resonance imaging (MRI) in models of ALPPS, major liver resection (LR) and portal vein ligation (PVL). Methods: Wistar rats were randomly allocated to ALPPS, LR or PVL. In contrast-enhanced MRI scans with gadoxetic acid (Primovist®), liver volume and function of the right median lobe (=future liver remnant, FLR) and the deportalized lobes (DPL) were assessed until post-operative day (POD) 5. Liver functionFLR/DPL was defined as the inverse value of time from injection of gadoxetic acid to the blood pool-corrected maximum signal intensityFLR/DPL multiplied by the volumeFLR/DPL. Results: In ALPPS (n = 6), LR (n = 6) and PVL (n = 6), volumeFLR and functionFLR increased proportionally, except on POD 1. Thereafter, functionFLR exceeded volumeFLR increase in LR and ALPPS, but not in PVL. Total liver function was significantly reduced after LR until POD 3, but never undercuts 60% of its pre-operative value following ALPPS and PVL. Discussion: This study shows for the first time that functional increase is proportional to volume increase in ALPPS using gadoxetic acid avidity in MRI.
AB - Background: This animal study investigates the hypothesis of an immature liver growth following ALPPS (associating liver partition and portal vein ligation for staged hepatectomy) by measuring liver volume and function using gadoxetic acid avidity in magnetic resonance imaging (MRI) in models of ALPPS, major liver resection (LR) and portal vein ligation (PVL). Methods: Wistar rats were randomly allocated to ALPPS, LR or PVL. In contrast-enhanced MRI scans with gadoxetic acid (Primovist®), liver volume and function of the right median lobe (=future liver remnant, FLR) and the deportalized lobes (DPL) were assessed until post-operative day (POD) 5. Liver functionFLR/DPL was defined as the inverse value of time from injection of gadoxetic acid to the blood pool-corrected maximum signal intensityFLR/DPL multiplied by the volumeFLR/DPL. Results: In ALPPS (n = 6), LR (n = 6) and PVL (n = 6), volumeFLR and functionFLR increased proportionally, except on POD 1. Thereafter, functionFLR exceeded volumeFLR increase in LR and ALPPS, but not in PVL. Total liver function was significantly reduced after LR until POD 3, but never undercuts 60% of its pre-operative value following ALPPS and PVL. Discussion: This study shows for the first time that functional increase is proportional to volume increase in ALPPS using gadoxetic acid avidity in MRI.
UR - http://www.scopus.com/inward/record.url?scp=85181825349&partnerID=8YFLogxK
U2 - https://doi.org/10.1016/j.hpb.2023.12.007
DO - https://doi.org/10.1016/j.hpb.2023.12.007
M3 - Article
C2 - 38185541
SN - 1365-182X
VL - 26
SP - 521
EP - 529
JO - HPB
JF - HPB
IS - 4
ER -