Assignment of the human UDP glucuronosyltransferase gene (UGT1A1) to chromosome region 2q37

H. H. van Es; A. Bout; J. Liu; L. Anderson; A. M. Duncan; P. Bosma; R. Oude Elferink; P. L. Jansen; J. R. Chowdhury; E. Schurr

doi:https://doi.org/10.1159/000133513

Assignment of the human UDP glucuronosyltransferase gene (UGT1A1) to chromosome region 2q37

H. H. van Es, A. Bout, J. Liu, L. Anderson, A. M. Duncan, P. Bosma, R. Oude Elferink, P. L. Jansen, J. R. Chowdhury, E. Schurr

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Abstract

UDP glucuronosyltransferases (UGTs) comprise a multigene family of drug-metabolizing enzymes. The sub-family of UGTs that conjugate bilirubin and phenolic compounds with glucuronic acid has been termed UGT1A1. In man, UGT1A1 isoforms are encoded by a single gene, UGT1A1. Protein isoforms encoded by UGT1A1 originate by alternative splicing. In the present study, we used the cDNA of UGT1A1*4, a bilirubin-conjugating isoform, to localize the UGT1A1 locus in the human genome. The UGT1A1 gene was assigned by in situ hybridization to chromosome region 2q37

Original language	English
Pages (from-to)	114-116
Journal	Cytogenetics and Cell Genetics
Volume	63
Issue number	2
DOIs	https://doi.org/10.1159/000133513
Publication status	Published - 1993

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https://doi.org/10.1159/000133513

Cite this

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title = "Assignment of the human UDP glucuronosyltransferase gene (UGT1A1) to chromosome region 2q37",

abstract = "UDP glucuronosyltransferases (UGTs) comprise a multigene family of drug-metabolizing enzymes. The sub-family of UGTs that conjugate bilirubin and phenolic compounds with glucuronic acid has been termed UGT1A1. In man, UGT1A1 isoforms are encoded by a single gene, UGT1A1. Protein isoforms encoded by UGT1A1 originate by alternative splicing. In the present study, we used the cDNA of UGT1A1*4, a bilirubin-conjugating isoform, to localize the UGT1A1 locus in the human genome. The UGT1A1 gene was assigned by in situ hybridization to chromosome region 2q37",

author = "{van Es}, {H. H.} and A. Bout and J. Liu and L. Anderson and Duncan, {A. M.} and P. Bosma and {Oude Elferink}, R. and Jansen, {P. L.} and Chowdhury, {J. R.} and E. Schurr",

year = "1993",

doi = "https://doi.org/10.1159/000133513",

language = "English",

volume = "63",

pages = "114--116",

journal = "Cytogenetics and Cell Genetics",

issn = "0301-0171",

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TY - JOUR

T1 - Assignment of the human UDP glucuronosyltransferase gene (UGT1A1) to chromosome region 2q37

AU - van Es, H. H.

AU - Bout, A.

AU - Liu, J.

AU - Anderson, L.

AU - Duncan, A. M.

AU - Bosma, P.

AU - Oude Elferink, R.

AU - Jansen, P. L.

AU - Chowdhury, J. R.

AU - Schurr, E.

PY - 1993

Y1 - 1993

N2 - UDP glucuronosyltransferases (UGTs) comprise a multigene family of drug-metabolizing enzymes. The sub-family of UGTs that conjugate bilirubin and phenolic compounds with glucuronic acid has been termed UGT1A1. In man, UGT1A1 isoforms are encoded by a single gene, UGT1A1. Protein isoforms encoded by UGT1A1 originate by alternative splicing. In the present study, we used the cDNA of UGT1A1*4, a bilirubin-conjugating isoform, to localize the UGT1A1 locus in the human genome. The UGT1A1 gene was assigned by in situ hybridization to chromosome region 2q37

AB - UDP glucuronosyltransferases (UGTs) comprise a multigene family of drug-metabolizing enzymes. The sub-family of UGTs that conjugate bilirubin and phenolic compounds with glucuronic acid has been termed UGT1A1. In man, UGT1A1 isoforms are encoded by a single gene, UGT1A1. Protein isoforms encoded by UGT1A1 originate by alternative splicing. In the present study, we used the cDNA of UGT1A1*4, a bilirubin-conjugating isoform, to localize the UGT1A1 locus in the human genome. The UGT1A1 gene was assigned by in situ hybridization to chromosome region 2q37

U2 - https://doi.org/10.1159/000133513

DO - https://doi.org/10.1159/000133513

M3 - Article

C2 - 8467709

SN - 0301-0171

VL - 63

SP - 114

EP - 116

JO - Cytogenetics and Cell Genetics

JF - Cytogenetics and Cell Genetics

IS - 2

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