TY - JOUR
T1 - Association between hepatic Triglyceride content and left Ventricular Diastolic Function in a Population-based cohort
T2 - The Netherlands Epidemiology of Obesity Study1
AU - Widya, Ralph L.
AU - De Mutsert, Renée
AU - Den Heijer, Martin
AU - Le Cessie, Saskia
AU - Rosendaal, Frits R.
AU - Wouter Jukema, J.
AU - Smit, Johannes W.A.
AU - De Roos, Albert
AU - Lamb, Hildo J.
N1 - Publisher Copyright: © 2015 RSNA.
PY - 2016/5
Y1 - 2016/5
N2 - Purpose: To investigate the association between hepatic triglyceride content and left ventricular (LV) diastolic function while taking potential confounding factors into account, including the components of the metabolic syndrome. Materials and Methods: The study was approved by the institutional review board, and all participants gave informed consent. In this cross-sectional analysis of baseline data from the Netherlands Epidemiology of Obesity study, a population-based, prospective cohort study, participants (45% men; mean age 6 standard deviation, 55.3 years ± 6.2) underwent magnetic resonance (MR) spectroscopy and MR imaging to assess hepatic triglyceride content and LV diastolic heart function (ratio of peak filling rates of the early filling phase and atrial contraction [E/A ratio]). Multivariate linear regression analysis was performed while adjusting for confounding factors, and results were additionally strati-fied according to body mass index. Results: Adjustment for age, sex, heart rate, alcohol consumption, pack-years of smoking, all components of the metabolic syndrome, and visceral adiposity attenuated crude observed associations. A 10-fold increase in hepatic triglyceride content was associated with a change in mean E/A ratio of 20.004 (95% confidence interval [CI]:-0.134, 0.125) in the total study population,-0.194 (95% CI:-0.430, 0.042) in the normal-weight subgroup, 0.079 (95% CI:-0.090, 0.248) in the overweight subgroup, and-0.109 (95% CI:-0.186,-0.032) in the obese subgroup. Conclusion: Fatty liver itself could, at least in obesity, pose a risk of myocardial dysfunction above and beyond known cardiovascular risk factors that are clustered within the metabolic syndrome. The association in the obese subgroup was small, and future studies with larger samples sizes are required to investigate to what extent the association exists and differs in normal-weight, overweight, and obese persons to unravel its clinical relevance.
AB - Purpose: To investigate the association between hepatic triglyceride content and left ventricular (LV) diastolic function while taking potential confounding factors into account, including the components of the metabolic syndrome. Materials and Methods: The study was approved by the institutional review board, and all participants gave informed consent. In this cross-sectional analysis of baseline data from the Netherlands Epidemiology of Obesity study, a population-based, prospective cohort study, participants (45% men; mean age 6 standard deviation, 55.3 years ± 6.2) underwent magnetic resonance (MR) spectroscopy and MR imaging to assess hepatic triglyceride content and LV diastolic heart function (ratio of peak filling rates of the early filling phase and atrial contraction [E/A ratio]). Multivariate linear regression analysis was performed while adjusting for confounding factors, and results were additionally strati-fied according to body mass index. Results: Adjustment for age, sex, heart rate, alcohol consumption, pack-years of smoking, all components of the metabolic syndrome, and visceral adiposity attenuated crude observed associations. A 10-fold increase in hepatic triglyceride content was associated with a change in mean E/A ratio of 20.004 (95% confidence interval [CI]:-0.134, 0.125) in the total study population,-0.194 (95% CI:-0.430, 0.042) in the normal-weight subgroup, 0.079 (95% CI:-0.090, 0.248) in the overweight subgroup, and-0.109 (95% CI:-0.186,-0.032) in the obese subgroup. Conclusion: Fatty liver itself could, at least in obesity, pose a risk of myocardial dysfunction above and beyond known cardiovascular risk factors that are clustered within the metabolic syndrome. The association in the obese subgroup was small, and future studies with larger samples sizes are required to investigate to what extent the association exists and differs in normal-weight, overweight, and obese persons to unravel its clinical relevance.
UR - http://www.scopus.com/inward/record.url?scp=84965164295&partnerID=8YFLogxK
U2 - https://doi.org/10.1148/radiol.2015150035
DO - https://doi.org/10.1148/radiol.2015150035
M3 - Article
C2 - 26812225
SN - 0033-8419
VL - 279
SP - 443
EP - 450
JO - Radiology
JF - Radiology
IS - 2
ER -