TY - JOUR
T1 - Association between Intraplaque Hemorrhage and Vascular Remodeling in Carotid Arteries
T2 - The Plaque at RISK (PARISK) Study
AU - Dilba, Kristine
AU - Van Dijk, Anouk C.
AU - Crombag, Geneviève A.J.C.
AU - Van Der Steen, Anton F.W.
AU - Daemen, Mat J.
AU - Koudstaal, Peter J.
AU - Nederkoorn, Paul J.
AU - Hendrikse, Jeroen
AU - Kooi, M. Eline
AU - Van Der Lugt, Aad
AU - Wentzel, Jolanda J.
N1 - Funding Information: This research was performed within the framework of the Center for Translational Molecular Medicine (www.ctmm.nl), project PARISK (Plaque At RISK; Grant 01C-202) and supported by the Dutch Heart Foundation. Kristina Dilba was in part supported by STW project number 10813. Publisher Copyright: © 2020 S. Karger AG, Basel. Copyright: All rights reserved.
PY - 2021/2
Y1 - 2021/2
N2 - Introduction: Vascular remodeling is a compensatory enlargement of the vessel wall in response to atherosclerotic plaque growth. We aimed to investigate the association between intraplaque hemorrhage (IPH), vascular remodeling, and luminal dimensions in recently symptomatic patients with mild to moderate carotid artery stenosis in which the differences in plaque size were taken into account. Materials and Methods: We assessed vessel dimensions on MRI of the symptomatic carotid artery in 164 patients from the Plaque At RISK study. This study included patients with recent ischemic neurological event and ipsilateral carotid artery stenosis <70%. The cross section with the largest wall area (WA) in the internal carotid artery (ICA) was selected for analysis. On this cross section, the following parameters were determined: WA, total vessel area (TVA), and lumen area (LA). Vascular remodeling was quantified as the remodeling ratio (RR) and was calculated as TVA at this position divided by the TVA in an unaffected distal portion of the ipsilateral ICA. Adjustment for WA was performed to correct for plaque size. Results: Plaques with IPH had a larger WA (0.56 vs. 0.46 cm2 p < 0.001), a smaller LA (0.17 vs. 0.22 cm2 p = 0.03), and a higher RR (2.0 vs. 1.9; p = 0.03) than plaques without IPH. After adjustment for WA, plaques containing IPH had a smaller LA (B =-0.052, p = 0.01) than plaques without IPH, but the RR was not different. Conclusion: After correcting for plaque size, plaques containing IPH had a smaller LA than plaques without IPH. However, RR was not different.
AB - Introduction: Vascular remodeling is a compensatory enlargement of the vessel wall in response to atherosclerotic plaque growth. We aimed to investigate the association between intraplaque hemorrhage (IPH), vascular remodeling, and luminal dimensions in recently symptomatic patients with mild to moderate carotid artery stenosis in which the differences in plaque size were taken into account. Materials and Methods: We assessed vessel dimensions on MRI of the symptomatic carotid artery in 164 patients from the Plaque At RISK study. This study included patients with recent ischemic neurological event and ipsilateral carotid artery stenosis <70%. The cross section with the largest wall area (WA) in the internal carotid artery (ICA) was selected for analysis. On this cross section, the following parameters were determined: WA, total vessel area (TVA), and lumen area (LA). Vascular remodeling was quantified as the remodeling ratio (RR) and was calculated as TVA at this position divided by the TVA in an unaffected distal portion of the ipsilateral ICA. Adjustment for WA was performed to correct for plaque size. Results: Plaques with IPH had a larger WA (0.56 vs. 0.46 cm2 p < 0.001), a smaller LA (0.17 vs. 0.22 cm2 p = 0.03), and a higher RR (2.0 vs. 1.9; p = 0.03) than plaques without IPH. After adjustment for WA, plaques containing IPH had a smaller LA (B =-0.052, p = 0.01) than plaques without IPH, but the RR was not different. Conclusion: After correcting for plaque size, plaques containing IPH had a smaller LA than plaques without IPH. However, RR was not different.
KW - Carotid atherosclerosis
KW - Intraplaque hemorrhage
KW - MRI
KW - Plaque analysis
KW - Vascular imaging
KW - Vascular remodeling
UR - http://www.scopus.com/inward/record.url?scp=85097838158&partnerID=8YFLogxK
U2 - https://doi.org/10.1159/000511935
DO - https://doi.org/10.1159/000511935
M3 - Article
C2 - 33271533
SN - 1015-9770
VL - 50
SP - 94
EP - 99
JO - Cerebrovascular diseases
JF - Cerebrovascular diseases
IS - 1
ER -