TY - JOUR
T1 - Association between osteocalcin and cognitive performance in healthy older adults
AU - Bradburn, Steven
AU - McPhee, Jamie S.
AU - Bagley, Liam
AU - Sipila, Sarianna
AU - Stenroth, Lauri
AU - Narici, Marco Vincenzo
AU - Pääsuke, Mati
AU - Gapeyeva, Helena
AU - Osborne, Gabrielle
AU - Sassano, Lorraine
AU - Meskers, Carel G. M.
AU - Maier, Andrea B.
AU - Hogrel, Jean-Yves
AU - Barnouin, Yoann
AU - Butler-Browne, Gillian
AU - Murgatroyd, Chris
PY - 2016/11
Y1 - 2016/11
N2 - cognitive deterioration and reductions of bone health coincide with increasing age. We examine the relationship between bone composition and plasma markers of bone remodelling with measures of cognitive performance in healthy adults. this cross-sectional study included 225 old (52% women, mean age: 74.4 ± 3.3 years) and 134 young (52% women, mean age: 23.4 ± 2.7 years) adult participants from the MyoAge project. Whole body bone mineral density was measured by dual-energy X-ray absorptiometry. Blood analyses included a panel of bone-related peptides (dickkopf-1, osteoprotegerin, osteocalcin (OC), osteopontin, sclerostin, parathyroid hormone and fibroblast growth factor 23), as well as serum calcium and 25-hydroxy vitamin D assays. A selection of cognitive domains (working memory capacity, episodic memory, executive functioning and global cognition) was assessed with a standardised neuropsychological test battery. adjusting for covariates and multiple testing revealed that plasma OC levels were positively associated with measures of executive functioning (β = 0.444, P < 0.001) and global cognition (β = 0.381, P = 0.001) in the older women. these correlative results demonstrate a positive association between OC, a factor known to regulate bone remodelling, with cognitive performance in older non-demented women. Further work should address possible mechanistic interpretations in humans
AB - cognitive deterioration and reductions of bone health coincide with increasing age. We examine the relationship between bone composition and plasma markers of bone remodelling with measures of cognitive performance in healthy adults. this cross-sectional study included 225 old (52% women, mean age: 74.4 ± 3.3 years) and 134 young (52% women, mean age: 23.4 ± 2.7 years) adult participants from the MyoAge project. Whole body bone mineral density was measured by dual-energy X-ray absorptiometry. Blood analyses included a panel of bone-related peptides (dickkopf-1, osteoprotegerin, osteocalcin (OC), osteopontin, sclerostin, parathyroid hormone and fibroblast growth factor 23), as well as serum calcium and 25-hydroxy vitamin D assays. A selection of cognitive domains (working memory capacity, episodic memory, executive functioning and global cognition) was assessed with a standardised neuropsychological test battery. adjusting for covariates and multiple testing revealed that plasma OC levels were positively associated with measures of executive functioning (β = 0.444, P < 0.001) and global cognition (β = 0.381, P = 0.001) in the older women. these correlative results demonstrate a positive association between OC, a factor known to regulate bone remodelling, with cognitive performance in older non-demented women. Further work should address possible mechanistic interpretations in humans
KW - Ageing
KW - Cognitive decline
KW - Journal Article
KW - Older people
KW - Osteocalcin
UR - http://www.scopus.com/inward/record.url?scp=85011571374&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85011571374&partnerID=8YFLogxK
U2 - https://doi.org/10.1093/ageing/afw137
DO - https://doi.org/10.1093/ageing/afw137
M3 - Article
C2 - 27515675
SN - 0002-0729
VL - 45
SP - 844
EP - 849
JO - Age and ageing
JF - Age and ageing
IS - 6
ER -