TY - JOUR
T1 - Association between Subcortical Vascular Lesion Location and Cognition
T2 - A Voxel-Based and Tract-Based Lesion-Symptom Mapping Study. The SMART-MR Study
AU - Biesbroek, J. Matthijs
AU - Kuijf, Hugo J.
AU - van der Graaf, Yolanda
AU - Vincken, Koen L.
AU - Postma, Albert
AU - Mali, Willem P. T. M.
AU - Biessels, Geert J.
AU - Geerlings, Mirjam I.
PY - 2013/4/8
Y1 - 2013/4/8
N2 - Introduction: Lacunar lesions (LLs) and white matter lesions (WMLs) affect cognition. We assessed whether lesions located in specific white matter tracts were associated with cognitive performance taking into account total lesion burden. Methods: Within the Second Manifestations of ARTerial disease Magnetic Resonance (SMART-MR) study, cross-sectional analyses were performed on 516 patients with manifest arterial disease. We applied an assumption-free voxel-based lesion-symptom mapping approach to investigate the relation between LL and WML locations on 1.5 Tesla brain MRI and compound scores of executive functioning, memory and processing speed. Secondly, a multivariable linear regression model was used to relate the regional volume of LLs and WMLs within specific white matter tracts to cognitive functioning. Results: Voxel-based lesion-symptom mapping identified several clusters of voxels with a significant correlation between WMLs and executive functioning, mostly located within the superior longitudinal fasciculus and anterior thalamic radiation. In the multivariable linear regression model, a statistically significant association was found between regional LL volume within the superior longitudinal fasciculus and anterior thalamic radiation and executive functioning after adjustment for total LL and WML burden. Conclusion: These findings identify the superior longitudinal fasciculus and anterior thalamic radiation as key anatomical structures in executive functioning and emphasize the role of strategically located vascular lesions in vascular cognitive impairment. © 2013 Biesbroek et al.
AB - Introduction: Lacunar lesions (LLs) and white matter lesions (WMLs) affect cognition. We assessed whether lesions located in specific white matter tracts were associated with cognitive performance taking into account total lesion burden. Methods: Within the Second Manifestations of ARTerial disease Magnetic Resonance (SMART-MR) study, cross-sectional analyses were performed on 516 patients with manifest arterial disease. We applied an assumption-free voxel-based lesion-symptom mapping approach to investigate the relation between LL and WML locations on 1.5 Tesla brain MRI and compound scores of executive functioning, memory and processing speed. Secondly, a multivariable linear regression model was used to relate the regional volume of LLs and WMLs within specific white matter tracts to cognitive functioning. Results: Voxel-based lesion-symptom mapping identified several clusters of voxels with a significant correlation between WMLs and executive functioning, mostly located within the superior longitudinal fasciculus and anterior thalamic radiation. In the multivariable linear regression model, a statistically significant association was found between regional LL volume within the superior longitudinal fasciculus and anterior thalamic radiation and executive functioning after adjustment for total LL and WML burden. Conclusion: These findings identify the superior longitudinal fasciculus and anterior thalamic radiation as key anatomical structures in executive functioning and emphasize the role of strategically located vascular lesions in vascular cognitive impairment. © 2013 Biesbroek et al.
UR - https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=84876003577&origin=inward
UR - https://www.ncbi.nlm.nih.gov/pubmed/23593238
U2 - https://doi.org/10.1371/journal.pone.0060541
DO - https://doi.org/10.1371/journal.pone.0060541
M3 - Article
C2 - 23593238
SN - 1932-6203
VL - 8
JO - PLOS ONE
JF - PLOS ONE
IS - 4
M1 - e60541
ER -