TY - JOUR
T1 - Association of early left ventricular dysfunction with advanced magnetic resonance white matter and gray matter brain measures
T2 - The CARDIA study
AU - Armstrong, Anderson C.
AU - Muller, Majon
AU - Ambale-Ventakesh, Bharath
AU - Halstead, Michael
AU - Kishi, Satoru
AU - Bryan, Nick
AU - Sidney, Stephen
AU - Correia, Luís C.L.
AU - Gidding, Samuel S.
AU - Launer, Lenore J.
AU - Lima, João A.C.
PY - 2017/11/1
Y1 - 2017/11/1
N2 - Introduction: Relations between heart failure and clinically manifested stroke are well known, but the associations between heart and brain early abnormalities are not totally clear. Aims: We explore relations of subclinical brain abnormalities with early cardiac dysfunction in a large healthy middle-aged biracial cohort. Methods: The CARDIA study enrolled 5115 young adults aged 18–30 years at baseline (1985–1986). We assessed 719 Caucasian and African American participants of the CARDIA study, with echocardiograms and brain MRI at follow-up year 25 (2010–2011). Echocardiography assessed aortic root diameter; LVEF; circumferential, longitudinal, and radial deformation. Cerebral MRI DTI, and, on a subset, ASL perfusion sequences were used to assess white matter fractional anisotropy and gray matter cerebral blood flow (CBF). Linear regression explored relations between cardiac parameters and cerebral measures, adjusting for anthropometrics, risk factors, and brain constitutional variation. Results: Mean age 50 ± 4 years, SBP 118 ± 15 mm Hg; 60% white, and 48% men. Mean CBF was 46 ± 9 mL/100 g/min, and white matter fractional anisotropy was 0.31 ± 0.02. Worse circumferential deformation and larger aortic root were related to worse white matter fractional anisotropy. Worse radial systolic deformation was related to worse CBF in multivariable models. LVEF did not relate to early brain abnormalities. Conclusions: In spite of no apparent effect of LV ejection fraction, early subclinical cardiac dysfunction and brain abnormalities are present and associated in middle-aged generally healthy individuals.
AB - Introduction: Relations between heart failure and clinically manifested stroke are well known, but the associations between heart and brain early abnormalities are not totally clear. Aims: We explore relations of subclinical brain abnormalities with early cardiac dysfunction in a large healthy middle-aged biracial cohort. Methods: The CARDIA study enrolled 5115 young adults aged 18–30 years at baseline (1985–1986). We assessed 719 Caucasian and African American participants of the CARDIA study, with echocardiograms and brain MRI at follow-up year 25 (2010–2011). Echocardiography assessed aortic root diameter; LVEF; circumferential, longitudinal, and radial deformation. Cerebral MRI DTI, and, on a subset, ASL perfusion sequences were used to assess white matter fractional anisotropy and gray matter cerebral blood flow (CBF). Linear regression explored relations between cardiac parameters and cerebral measures, adjusting for anthropometrics, risk factors, and brain constitutional variation. Results: Mean age 50 ± 4 years, SBP 118 ± 15 mm Hg; 60% white, and 48% men. Mean CBF was 46 ± 9 mL/100 g/min, and white matter fractional anisotropy was 0.31 ± 0.02. Worse circumferential deformation and larger aortic root were related to worse white matter fractional anisotropy. Worse radial systolic deformation was related to worse CBF in multivariable models. LVEF did not relate to early brain abnormalities. Conclusions: In spite of no apparent effect of LV ejection fraction, early subclinical cardiac dysfunction and brain abnormalities are present and associated in middle-aged generally healthy individuals.
KW - cardiac strain
KW - cerebrovascular disorders
KW - myocardial dysfunction
UR - http://www.scopus.com/inward/record.url?scp=85033233818&partnerID=8YFLogxK
U2 - https://doi.org/10.1111/echo.13695
DO - https://doi.org/10.1111/echo.13695
M3 - Article
C2 - 29114921
SN - 0742-2822
VL - 34
SP - 1617
EP - 1622
JO - Echocardiography
JF - Echocardiography
IS - 11
ER -