TY - JOUR
T1 - Association of residual plasma viremia and intima-media thickness in antiretroviral-treated patients with controlled human immunodeficiency virus infection
AU - Boyd, Anders
AU - Meynard, Jean-Luc
AU - Morand-Joubert, Laurence
AU - Michon, Adrien
AU - Boccara, Franck
AU - Bastard, Jean-Philippe
AU - Samri, Assia
AU - Haddour, Nabila
AU - Mallat, Ziad
AU - Capeau, Jacqueline
AU - For The Collaboration In Hiv, Inflammation And Cardiovascular Disease Study
AU - Desvarieux, Moïse
AU - Girard, Pierre-Marie
PY - 2014/11/21
Y1 - 2014/11/21
N2 - Methods: This cross-sectional study included 47 male, never-smoking, non-diabetic patients with ≥4 years of ART and controlled HIV-replication (HIV-viral load, VL <20 copies/mL for≥1 year). Residual HIV-VL was measured using an ultrasensitive assay (quantification limit: 1 copy/ml). Patients were categorized as having detectable (D; 1-20 copies/mL, n514) or undetectable (UD;<1 copies/mL, n533) HIV-VL. Linear regression was used to model the difference in total carotid intima-media thickness [c-IMT, measures averaged across common carotid artery (cca), bifurcation, and internal carotid artery] and cca-IMT alone across detection groups. Multivariable models were constructed for each endpoint in a forward-stepwise approach.
AB - Methods: This cross-sectional study included 47 male, never-smoking, non-diabetic patients with ≥4 years of ART and controlled HIV-replication (HIV-viral load, VL <20 copies/mL for≥1 year). Residual HIV-VL was measured using an ultrasensitive assay (quantification limit: 1 copy/ml). Patients were categorized as having detectable (D; 1-20 copies/mL, n514) or undetectable (UD;<1 copies/mL, n533) HIV-VL. Linear regression was used to model the difference in total carotid intima-media thickness [c-IMT, measures averaged across common carotid artery (cca), bifurcation, and internal carotid artery] and cca-IMT alone across detection groups. Multivariable models were constructed for each endpoint in a forward-stepwise approach.
KW - Adult
KW - Anti-Retroviral Agents/administration & dosage
KW - Atherosclerosis/blood
KW - Carotid Artery, Common/pathology
KW - Carotid Intima-Media Thickness
KW - Cross-Sectional Studies
KW - HIV Infections/blood
KW - HIV-1
KW - Humans
KW - Male
KW - Middle Aged
KW - Viremia/drug therapy
UR - https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=84912084734&origin=inward
UR - https://www.ncbi.nlm.nih.gov/pubmed/25415323
U2 - https://doi.org/10.1371/journal.pone.0113876
DO - https://doi.org/10.1371/journal.pone.0113876
M3 - Article
C2 - 25415323
SN - 1932-6203
VL - 9
JO - PLOS ONE
JF - PLOS ONE
IS - 11
M1 - e113876
ER -