Association of visual function and ganglion cell layer thickness in patients with diabetes mellitus type 1 and no or minimal diabetic retinopathy

Hille W. van Dijk; Frank D. Verbraak; Marilette Stehouwer; Pauline H. B. Kok; Mona K. Garvin; Milan Sonka; J. Hans DeVries; Reinier O. Schlingemann; Michael D. Abràmoff

doi:https://doi.org/10.1016/j.visres.2010.08.024

Association of visual function and ganglion cell layer thickness in patients with diabetes mellitus type 1 and no or minimal diabetic retinopathy

Hille W. van Dijk, Frank D. Verbraak, Marilette Stehouwer, Pauline H. B. Kok, Mona K. Garvin, Milan Sonka, J. Hans DeVries, Reinier O. Schlingemann, Michael D. Abràmoff

Research output: Contribution to journal › Article › Academic › peer-review

106 Citations (Scopus)

Abstract

Diabetic retinopathy (DR) classically presents with micro-aneurysms, small haemorrhages and/or lipoprotein exudates. Several studies have indicated that neural loss occurs in DR even before vascular damage can be observed. This study evaluated the possible relationship between structure (spectral domain-optical coherence tomography) and function (Rarebit visual field test) in patients with type 1 diabetes mellitus and no or minimal diabetic retinopathy (DR). Results demonstrated loss of macular visual function and corresponding thinning of the ganglion cell layer (GCL) in the pericentral area of the macula of diabetic patients (Rs = 0.65, p <0.001). In multivariable logistic regression analysis, GCL thickness remained an independent predictor of decreased visual function (OR 1.5, 95% CI 1.1-2.1). Early DR seems to include a neurodegenerative component. (C) 2010 Elsevier Ltd. All rights reserved

Original language	English
Pages (from-to)	224-228
Journal	Vision research
Volume	51
Issue number	2
DOIs	https://doi.org/10.1016/j.visres.2010.08.024
Publication status	Published - 2011

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Cite this

van Dijk, H. W., Verbraak, F. D., Stehouwer, M., Kok, P. H. B., Garvin, M. K., Sonka, M., DeVries, J. H., Schlingemann, R. O., & Abràmoff, M. D. (2011). Association of visual function and ganglion cell layer thickness in patients with diabetes mellitus type 1 and no or minimal diabetic retinopathy. Vision research, 51(2), 224-228. https://doi.org/10.1016/j.visres.2010.08.024

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title = "Association of visual function and ganglion cell layer thickness in patients with diabetes mellitus type 1 and no or minimal diabetic retinopathy",

abstract = "Diabetic retinopathy (DR) classically presents with micro-aneurysms, small haemorrhages and/or lipoprotein exudates. Several studies have indicated that neural loss occurs in DR even before vascular damage can be observed. This study evaluated the possible relationship between structure (spectral domain-optical coherence tomography) and function (Rarebit visual field test) in patients with type 1 diabetes mellitus and no or minimal diabetic retinopathy (DR). Results demonstrated loss of macular visual function and corresponding thinning of the ganglion cell layer (GCL) in the pericentral area of the macula of diabetic patients (Rs = 0.65, p <0.001). In multivariable logistic regression analysis, GCL thickness remained an independent predictor of decreased visual function (OR 1.5, 95% CI 1.1-2.1). Early DR seems to include a neurodegenerative component. (C) 2010 Elsevier Ltd. All rights reserved",

author = "{van Dijk}, {Hille W.} and Verbraak, {Frank D.} and Marilette Stehouwer and Kok, {Pauline H. B.} and Garvin, {Mona K.} and Milan Sonka and DeVries, {J. Hans} and Schlingemann, {Reinier O.} and Abr{\`a}moff, {Michael D.}",

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T1 - Association of visual function and ganglion cell layer thickness in patients with diabetes mellitus type 1 and no or minimal diabetic retinopathy

AU - van Dijk, Hille W.

AU - Verbraak, Frank D.

AU - Stehouwer, Marilette

AU - Kok, Pauline H. B.

AU - Garvin, Mona K.

AU - Sonka, Milan

AU - DeVries, J. Hans

AU - Schlingemann, Reinier O.

AU - Abràmoff, Michael D.

PY - 2011

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AB - Diabetic retinopathy (DR) classically presents with micro-aneurysms, small haemorrhages and/or lipoprotein exudates. Several studies have indicated that neural loss occurs in DR even before vascular damage can be observed. This study evaluated the possible relationship between structure (spectral domain-optical coherence tomography) and function (Rarebit visual field test) in patients with type 1 diabetes mellitus and no or minimal diabetic retinopathy (DR). Results demonstrated loss of macular visual function and corresponding thinning of the ganglion cell layer (GCL) in the pericentral area of the macula of diabetic patients (Rs = 0.65, p <0.001). In multivariable logistic regression analysis, GCL thickness remained an independent predictor of decreased visual function (OR 1.5, 95% CI 1.1-2.1). Early DR seems to include a neurodegenerative component. (C) 2010 Elsevier Ltd. All rights reserved

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