TY - JOUR
T1 - Associations between primary motor cortex organization, motor control and sensory tests during the clinical course of low back pain. A protocol for a cross-sectional and longitudinal case-control study
AU - Klerx, S.P.
AU - Bruijn, S.M.
AU - Kiers, H.
AU - Coppieters, M.W.
AU - Twisk, J.W.R.
AU - Pool-Goudzwaard, A.L.
N1 - Funding Information: This work was supported by The Netherlands Organization for Scientific Research (NWO), grant number 023.010.068. Costs for the MRIs were covered by the Dutch Association for Quality in Physiotherapy and the Vrije Universiteit Amsterdam. SB was funded by a VIDI grant (016.Vidi.178.014) from The Netherlands Organization for Scientific Research (NWO). The authors would like to thank all participants. The authors are also thankful to Lotte Tiessen, Zahir Haddag, Sebastiaan van Osch, Maurits Eveleens, Maarten van de Beek and Nils Breebaart who provided assistance during the measurements. We want to thank Fang Jin, Moira van Leeuwen, David Xian and Martin Meyer who provided assistance during the pilot measurements and Bert Clairbois and Bert Coolen for their technical assistance. Funding Information: This work was supported by The Netherlands Organization for Scientific Research ( NWO ), grant number 023.010.068. Costs for the MRIs were covered by the Dutch Association for Quality in Physiotherapy and the Vrije Universiteit Amsterdam. SB was funded by a VIDI grant (016.Vidi.178.014) from The Netherlands Organization for Scientific Research ( NWO ). Publisher Copyright: © 2022 The Authors
PY - 2022/12/1
Y1 - 2022/12/1
N2 - © 2022 The AuthorsBackground: In people with low back pain (LBP), altered motor control has been related to reorganization of the primary motor cortex (M1). Sensory impairments in LBP have also been suggested to be associated with reorganization of M1. Little is known about reorganization of M1 over time in people with LBP, and whether it relates to changes in motor control and sensory impairments and recovery. This study aims to investigate 1) differences in organization of M1 of trunk muscles between people with and without LBP, and whether the organization of M1 relates to motor control and sensory impairments (cross-sectional component) and 2) reorganization of M1 over time and its relation with changes in motor control and sensory impairments and experienced recovery (longitudinal component). Methods: A case-control study with a cross-sectional and five-week longitudinal component is conducted in participants with LBP (N = 25) and participants without LBP (N = 25). Participants with LBP received usual care physiotherapy. Various tests were administered at baseline and follow-up. Following an anatomical MRI, organization of M1 (Center of Gravity and Area of the cortical representation of trunk muscles) was determined using transcranial magnetic stimulation. Quantitative sensory testing, a spiral-tracking motor control test, graphesthesia, two-point discrimination threshold and various self-reported questionnaires were also assessed. Multivariate multilevel analysis will be used for statistical analysis. Conclusion: We will address the gaps in knowledge about the association between reorganization of M1 and motor control and sensory tests during the clinical course of LBP. This study is registered at DOI 10.17605/OSF.IO/5C8ZG.
AB - © 2022 The AuthorsBackground: In people with low back pain (LBP), altered motor control has been related to reorganization of the primary motor cortex (M1). Sensory impairments in LBP have also been suggested to be associated with reorganization of M1. Little is known about reorganization of M1 over time in people with LBP, and whether it relates to changes in motor control and sensory impairments and recovery. This study aims to investigate 1) differences in organization of M1 of trunk muscles between people with and without LBP, and whether the organization of M1 relates to motor control and sensory impairments (cross-sectional component) and 2) reorganization of M1 over time and its relation with changes in motor control and sensory impairments and experienced recovery (longitudinal component). Methods: A case-control study with a cross-sectional and five-week longitudinal component is conducted in participants with LBP (N = 25) and participants without LBP (N = 25). Participants with LBP received usual care physiotherapy. Various tests were administered at baseline and follow-up. Following an anatomical MRI, organization of M1 (Center of Gravity and Area of the cortical representation of trunk muscles) was determined using transcranial magnetic stimulation. Quantitative sensory testing, a spiral-tracking motor control test, graphesthesia, two-point discrimination threshold and various self-reported questionnaires were also assessed. Multivariate multilevel analysis will be used for statistical analysis. Conclusion: We will address the gaps in knowledge about the association between reorganization of M1 and motor control and sensory tests during the clinical course of LBP. This study is registered at DOI 10.17605/OSF.IO/5C8ZG.
KW - Cortical organization
KW - Low back pain
KW - Motor control
KW - Sensory tests
KW - Transcranial magnetic stimulation
UR - http://www.scopus.com/inward/record.url?scp=85141325373&partnerID=8YFLogxK
U2 - https://doi.org/10.1016/j.conctc.2022.101022
DO - https://doi.org/10.1016/j.conctc.2022.101022
M3 - Article
C2 - 36387987
SN - 2451-8654
VL - 30
JO - Contemporary Clinical Trials Communications
JF - Contemporary Clinical Trials Communications
M1 - 101022
ER -