TY - JOUR
T1 - Associations between Staphylococcus aureus Genotype, Infection, and In-Hospital Mortality: A Nested Case-Control Study
AU - Wertheim, Heiman F. L.
AU - van Leeuwen, Willem B.
AU - Snijders, Susan
AU - Vos, Margreet C.
AU - Voss, Andreas
AU - Vandenbroucke-Grauls, Christina M. J. E.
AU - Kluytmans, Jan A. J. W.
AU - Verbrugh, Henri A.
AU - van Belkum, Alex
PY - 2005
Y1 - 2005
N2 - We screened 14,008 adult nonsurgical patients for Staphylococcus aureus nasal carriage at hospital admission and assessed them for invasive S. aureus disease and in-hospital mortality. Multilocus sequence typing was performed on endogenous invasive strains and nasal strains of matched asymptomatic carriers to investigate whether virulent clones could be identified in nasal carriers. Clonal complex (CC) 45 was significantly underrepresented (odds ratio [OR], 0.16 [95% confidence interval {CI}, 0.04-0.59]) and CC30 was overrepresented (not statistically significant) among invasive strains (OR, 1.91 [95% CI, 0.91-4.0]). The distribution of CCs of invasive S. aureus strains in noncarriers did not differ from that in carriers. Those infected with S. aureus strains belonging to a CC had higher mortality than those infected with strains not belonging to a CC (P <.05), which indicates the coevolution of S. aureus virulence and spread in humans
AB - We screened 14,008 adult nonsurgical patients for Staphylococcus aureus nasal carriage at hospital admission and assessed them for invasive S. aureus disease and in-hospital mortality. Multilocus sequence typing was performed on endogenous invasive strains and nasal strains of matched asymptomatic carriers to investigate whether virulent clones could be identified in nasal carriers. Clonal complex (CC) 45 was significantly underrepresented (odds ratio [OR], 0.16 [95% confidence interval {CI}, 0.04-0.59]) and CC30 was overrepresented (not statistically significant) among invasive strains (OR, 1.91 [95% CI, 0.91-4.0]). The distribution of CCs of invasive S. aureus strains in noncarriers did not differ from that in carriers. Those infected with S. aureus strains belonging to a CC had higher mortality than those infected with strains not belonging to a CC (P <.05), which indicates the coevolution of S. aureus virulence and spread in humans
U2 - https://doi.org/10.1086/444427
DO - https://doi.org/10.1086/444427
M3 - Article
C2 - 16136462
SN - 0022-1899
VL - 192
SP - 1196
EP - 1200
JO - Journal of infectious diseases
JF - Journal of infectious diseases
IS - 7
ER -