Associations of different body fat deposits with serum 25-hydroxyvitamin D concentrations

Rachida Rafiq, Floor Walschot, Paul Lips, Hildo J. Lamb, Albert de Roos, Frits R. Rosendaal, Martin den Heijer, Renate T. de Jongh, Renée de Mutsert

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Background & aims: Obesity is a well-established risk factor of vitamin D deficiency. However, it is unclear which fat deposit is most strongly related to serum 25-hydroxyvitamin D (25(OH)D) concentrations. Our aim was to distinguish the specific contributions of total body fat (TBF), abdominal subcutaneous adipose tissue (aSAT), visceral adipose tissue (VAT) and hepatic fat on 25(OH)D concentrations. Methods: We performed a cross-sectional analysis of the Netherlands Epidemiology of Obesity study, a population-based cohort study. We used linear regression analyses to examine associations of TBF, aSAT, VAT (n = 2441) and hepatic fat (n = 1980) with 25(OH)D concentrations. Standardized values were used to compare the different fat deposits. Results: Mean (SD) age and 25(OH)D concentrations of the study population was 56 (6) years and 70.8 (24.2) nmol/L, respectively. TBF was inversely associated with 25(OH)D concentrations in women, but not in men. One percent higher TBF was associated with 0.40 nmol/L (95%CI: −0.67 to −0.13) lower 25(OH)D. aSAT was not associated with 25(OH)D concentrations. One cm2 higher VAT was associated with 0.05 nmol/L (−0.09 to −0.02) lower 25(OH)D in men, and 0.06 nmol/L (−0.10 to −0.01) lower 25(OH)D in women. Hepatic fat was only associated with 25(OH)D in men. A tenfold increase in hepatic fat was associated with 6.21 nmol/L (−10.70 to −1.73) lower 25(OH)D. Regressions with standardized values showed VAT was most strongly related to 25(OH)D. Conclusions: In women, TBF and VAT were inversely related to 25(OH)D concentrations. In men, VAT and hepatic fat were inversely related to 25(OH)D concentrations. In both groups, VAT was most strongly associated with 25(OH)D concentrations.
Original languageEnglish
Pages (from-to)2851-2857
Number of pages7
JournalClinical Nutrition
Issue number6
Early online date2019
Publication statusPublished - 1 Dec 2019


  • Hepatic fat
  • Obesity
  • Subcutaneous adipose tissue
  • Total body fat
  • Visceral adipose tissue
  • Vitamin D

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