TY - JOUR
T1 - Associations of the oral microbiota and Candida with taste, smell, appetite and undernutrition in older adults
AU - Fluitman, K.S.
AU - van den Broek, T.J.
AU - Nieuwdorp, M.
AU - Visser, M.
AU - IJzerman, R.G.
AU - Keijser, B.J.F.
N1 - Funding Information: This study was supported by the European Union Horizon 2020 PROMISS Project ‘PRevention Of Malnutrition In Senior Subjects in the EU’ (Grant Agreement No. 678732). The content only reflects the author’s view and the Commission is not responsible for any use that may be made of the information it contains. The Longitudinal Aging Study Amsterdam is supported by a grant from the Netherlands Ministry of Health Welfare and Sports, Directorate of Long-Term Care. The LASA data collection in 2012–2013 was financially supported by the Netherlands Organization for Scientific Research (NWO) in the framework of the project “New Cohorts of young old in the twenty-first century” (File Number 480-10-014). Publisher Copyright: © 2021, The Author(s).
PY - 2021/12/1
Y1 - 2021/12/1
N2 - © 2021, The Author(s).Poor taste and smell function are widely thought to contribute to the development of poor appetite and undernutrition in older adults. It has been hypothesized that the oral microbiota play a role as well, but evidence is scarce. In a cross-sectional cohort of 356 older adults, we performed taste and smell tests, collected anthropometric measurements and tongue swabs for analysis of microbial composition (16S rRNA sequencing) and Candida albicans abundance (qPCR). Older age, edentation, poor smell and poor appetite were associated with lower alpha diversity and explained a significant amount of beta diversity. Moreover, a lower Streptococcus salivarius abundance was associated with poor smell identification score, whereas high C. albicans abundance seemed to be associated with poor smell discrimination score. In our population, neither the tongue microbiota, nor C. albicans were associated with poor taste or directly with undernutrition. Our findings do suggest a host-microbe interaction with regard to smell perception and appetite.
AB - © 2021, The Author(s).Poor taste and smell function are widely thought to contribute to the development of poor appetite and undernutrition in older adults. It has been hypothesized that the oral microbiota play a role as well, but evidence is scarce. In a cross-sectional cohort of 356 older adults, we performed taste and smell tests, collected anthropometric measurements and tongue swabs for analysis of microbial composition (16S rRNA sequencing) and Candida albicans abundance (qPCR). Older age, edentation, poor smell and poor appetite were associated with lower alpha diversity and explained a significant amount of beta diversity. Moreover, a lower Streptococcus salivarius abundance was associated with poor smell identification score, whereas high C. albicans abundance seemed to be associated with poor smell discrimination score. In our population, neither the tongue microbiota, nor C. albicans were associated with poor taste or directly with undernutrition. Our findings do suggest a host-microbe interaction with regard to smell perception and appetite.
UR - http://www.scopus.com/inward/record.url?scp=85120609414&partnerID=8YFLogxK
U2 - https://doi.org/10.1038/s41598-021-02558-8
DO - https://doi.org/10.1038/s41598-021-02558-8
M3 - Article
C2 - 34853371
SN - 2045-2322
VL - 11
JO - Scientific reports
JF - Scientific reports
IS - 1
M1 - 23254
ER -
