Abstract
PURPOSE OF REVIEW: Asymptomatic bacteriuria (ASB) and urinary tract infections (UTIs) in women with diabetes mellitus and during pregnancy are common and can have far-reaching consequences for the woman and neonate. This review describes epidemiology, risk factors, complications and treatment of UTI and ASB according to recent developments in these two groups.
RECENT FINDINGS: Most articles addressing the epidemiology and risk factors of ASB and UTI in diabetic and pregnant women confirmed existing knowledge. New insights were obtained in the association between sodium-glucose cotransporter-2 (SGLT2) inhibitors, as medication for diabetes mellitus type 2, and a small increased risk for UTI due to glucosuria and the possible negative effects of UTI, including urosepsis,on bladder and kidney function in diabetic women. Predominantly, potential long-term effects of antibiotic treatment of ASB or UTI during pregnancy on the neonate have received attention, including antibiotic resistance and epilepsy.
SUMMARY: SGLT2 inhibitors were associated with a small increased risk for UTI, UTI in diabetic women may lead to bladder and kidney dysfunction, and antibiotic treatment of ASB and UTI during pregnancy was associated with long-term effects on the neonate. Up-to-date research on the effectiveness and long-term effects of ASB screening and treatment policies, including group B Streptococcus bacteriuria in pregnancy, is warranted to inform clinical practice.
Original language | English |
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Pages (from-to) | 108-114 |
Number of pages | 7 |
Journal | Current opinion in infectious diseases |
Volume | 27 |
Issue number | 1 |
DOIs | |
Publication status | Published - Feb 2014 |
Keywords
- Anti-Bacterial Agents/therapeutic use
- Asymptomatic Infections/epidemiology
- Bacteriuria/drug therapy
- Diabetes Complications
- Female
- Humans
- Pregnancy
- Pregnancy Complications, Infectious
- Risk Factors
- Urinary Tract Infections/drug therapy