@article{baea297bd2d74233929108aa36837eae,
title = "Attention-deficit/hyperactivity disorder polygenic risk scores predict attention problems in a population-based sample of children",
abstract = "Objective: Clinically, attention-deficit/hyperactivity disorder (ADHD) is characterized by hyperactivity, impulsivity, and inattention and is among the most common childhood disorders. These same traits that define ADHD are variable in the general population, and the clinical diagnosis may represent the extreme end of a continuous distribution of inattentive and hyperactive behaviors. This hypothesis can be tested by assessing the predictive value of polygenic risk scores derived from a discovery sample of ADHD patients in a target sample from the general population with continuous scores of inattention and hyperactivity. In addition, the genetic overlap between ADHD and continuous ADHD scores can be tested across rater and age.",
keywords = "ADHD, attention problems, dimensional models, genetics, polygenic scores",
author = "Groen-Blokhuis, {Maria M.} and Middeldorp, {Christel M.} and Kees-Jan Kan and Abdel Abdellaoui and {van Beijsterveldt}, {Catharina E. M.} and Ehli, {Erik A.} and Davies, {Gareth E.} and Scheet, {Paul A.} and Xiangjun Xiao and Hudziak, {James J.} and Jouke-Jan Hottenga and Neale, {Ben M.} and Boomsma, {Dorret I.}",
note = "Funding Information: Disclosure: Dr. Hudziak has received grant or research funding from the National Institutes of Health and the National Institute of Diabetes and Digestive and Kidney Disease. His primary appointment is with the University of Vermont. He has additional appointments with Erasmus University in Rotterdam, Netherlands, Washington University School of Medicine in St. Louis, Dartmouth School of Medicine in Hanover, New Hampshire, and Avera Institute of Human Behavioral Genetics in Sioux Falls, South Dakota. Drs. Groen-Blokhuis, Middeldorp, Kan, van Beijsterveldt, Ehli, Davies, Scheet, Hottenga, Neale, and Boomsma, and Mr. Abdellaoui and Mr. Xiao report no biomedical financial interests or potential conflicts of interest. Funding Information: This project was supported by ARRA RC2 2MH08995; the European Research Council (Genetics of Mental Illness, ERC-230374); Spinozapremie (NWO/SPI 56-464-14192); Neuroscience Campus Amsterdam (NCA) and the EMGO+ Institution; twin-family database for behavior genetics and genomics studies (NWO 480-04-004); Genetic influences on stability and change in psychopathology from childhood to young adulthood (ZonMW 912-10-020). Publisher Copyright: {\textcopyright} 2014 American Academy of Child and Adolescent Psychiatry.",
year = "2014",
month = oct,
day = "1",
doi = "https://doi.org/10.1016/j.jaac.2014.06.014",
language = "English",
volume = "53",
pages = "1123--1129.e6",
journal = "Journal of the American Academy of Child and Adolescent Psychiatry",
issn = "0890-8567",
publisher = "Elsevier Limited",
number = "10",
}