TY - JOUR
T1 - Attenuation coefficient estimation in Fourier-domain OCT of multi-layered phantoms
AU - GHAFARYASL, BABAK
AU - VERMEER, KOENRAAD A.
AU - KALKMAN, JEROEN
AU - CALLEWAERT, TOM
AU - DE BOER, JOHANNES F.
AU - VAN VLIET, LUCAS J.
N1 - Funding Information: Acknowledgment. This research was funded by the Netherlands Organization for Health Research and Development (ZonMw) TOP grant (91212061). We would like to acknowledge Jelmer Weda, BSc, (Department of Physics and Astronomy, Vrije Universiteit Amsterdam, The Netherlands) for his technical support in this work. Publisher Copyright: © 2021 Optical Society of America. Copyright: Copyright 2021 Elsevier B.V., All rights reserved.
PY - 2021/5/1
Y1 - 2021/5/1
N2 - Optical properties, such as the attenuation coefficients of multi-layer tissue samples, could be used as a biomarker for diagnosis and disease progression in clinical practice. In this paper, we present a method to estimate the attenuation coefficients in a multi-layer sample by fitting a single scattering model for the OCT signal to the recorded OCT signal. In addition, we employ numerical simulations to obtain the theoretically achievable precision and accuracy of the estimated parameters under various experimental conditions. Finally, the method is applied to two sets of measurements obtained from a multi-layer phantom by two experimental OCT systems: One with a large and one with a small Rayleigh length. Numerical and experimental results show an accurate estimation of the attenuation coefficients when using multiple B-scans.
AB - Optical properties, such as the attenuation coefficients of multi-layer tissue samples, could be used as a biomarker for diagnosis and disease progression in clinical practice. In this paper, we present a method to estimate the attenuation coefficients in a multi-layer sample by fitting a single scattering model for the OCT signal to the recorded OCT signal. In addition, we employ numerical simulations to obtain the theoretically achievable precision and accuracy of the estimated parameters under various experimental conditions. Finally, the method is applied to two sets of measurements obtained from a multi-layer phantom by two experimental OCT systems: One with a large and one with a small Rayleigh length. Numerical and experimental results show an accurate estimation of the attenuation coefficients when using multiple B-scans.
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U2 - https://doi.org/10.1364/BOE.415079
DO - https://doi.org/10.1364/BOE.415079
M3 - Article
SN - 2156-7085
VL - 12
SP - 2744
EP - 2758
JO - Biomedical Optics Express
JF - Biomedical Optics Express
IS - 5
ER -