TY - GEN
T1 - Automatic segmentation of the preterm neonatal brain with MRI using supervised classification
AU - Chita, Sabina M.
AU - Benders, Manon
AU - Moeskops, Pim
AU - Kersbergen, Karina J.
AU - Viergever, Max A.
AU - Isgum, Ivana
PY - 2013
Y1 - 2013
N2 - Cortical folding ensues around 13-14 weeks gestational age and a qualitative analysis of the cortex around this period is required to observe and better understand the folds arousal. A quantitative assessment of cortical folding can be based on the cortical surface area, extracted from segmentations of unmyelinated white matter (UWM), cortical grey matter (CoGM) and cerebrospinal uid in the extracerebral space (CSF). This work presents a method for automatic segmentation of these tissue types in preterm infants. A set of T1- and T2-weighted images of ten infants scanned at 30 weeks postmenstrual age was used. The reference standard was obtained by manual expert segmentation. The method employs supervised pixel classification in three subsequent stages. The classification is performed based on the set of spatial and texture features. Segmentation results are evaluated in terms of Dice coefficient (DC), Hausdorff distance (HD), and modified Hausdorff distance (MHD) defined as 95th percentile of the HD. The method achieved average DC of 0.94 for UWM, 0.73 for CoGM and 0.86 for CSF. The average HD and MHD were 6.89 mm and 0.34 mm for UWM, 6.49 mm and 0.82 mm for CoGM, and 7.09 mm and 0.79 mm for CSF, respectively. The presented method can provide volumetric measurements of the segmented tissues, and it enables quantification of cortical characteristics. Therefore, the method provides a basis for evaluation of clinical relevance of these biomarkers in the given population. © 2013 SPIE.
AB - Cortical folding ensues around 13-14 weeks gestational age and a qualitative analysis of the cortex around this period is required to observe and better understand the folds arousal. A quantitative assessment of cortical folding can be based on the cortical surface area, extracted from segmentations of unmyelinated white matter (UWM), cortical grey matter (CoGM) and cerebrospinal uid in the extracerebral space (CSF). This work presents a method for automatic segmentation of these tissue types in preterm infants. A set of T1- and T2-weighted images of ten infants scanned at 30 weeks postmenstrual age was used. The reference standard was obtained by manual expert segmentation. The method employs supervised pixel classification in three subsequent stages. The classification is performed based on the set of spatial and texture features. Segmentation results are evaluated in terms of Dice coefficient (DC), Hausdorff distance (HD), and modified Hausdorff distance (MHD) defined as 95th percentile of the HD. The method achieved average DC of 0.94 for UWM, 0.73 for CoGM and 0.86 for CSF. The average HD and MHD were 6.89 mm and 0.34 mm for UWM, 6.49 mm and 0.82 mm for CoGM, and 7.09 mm and 0.79 mm for CSF, respectively. The presented method can provide volumetric measurements of the segmented tissues, and it enables quantification of cortical characteristics. Therefore, the method provides a basis for evaluation of clinical relevance of these biomarkers in the given population. © 2013 SPIE.
UR - https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=84878332617&origin=inward
U2 - https://doi.org/10.1117/12.2006753
DO - https://doi.org/10.1117/12.2006753
M3 - Conference contribution
VL - 8669
T3 - Progress in Biomedical Optics and Imaging - Proceedings of SPIE
BT - Medical Imaging 2013: Image Processing
T2 - Medical Imaging 2013: Image Processing
Y2 - 10 February 2013 through 12 February 2013
ER -