Abstract
The activity of integrins on leukocytes is tightly controlled, and their adhesion capacity shifts rapidly when cells emigrate from the blood to the tissues. The leukocyte-specific beta2 integrin LFA-1 (alphaLbeta2) is the most important integrin expressed by leukocytes that regulate lymphocyte migration and the initiation of an immune response through binding to ICAM-1,-2 or-3. The binding activity of LFA-1 is rapidly altered by intracellular stimuli that activate LFA-1. Although alterations in the affinity of LFA-1, which leads to enhanced ICAM-1 binding, have been proposed, evidence is emerging that dynamic reorganisation of LFA-1 into microclusters is the major mechanism that regulates its binding capacity.
Original language | English |
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Pages (from-to) | 542-7 |
Number of pages | 6 |
Journal | Current opinion in cell biology |
Volume | 12 |
Issue number | 5 |
Publication status | Published - Oct 2000 |
Keywords
- Animals
- Binding, Competitive
- Cell Adhesion
- Cell Adhesion Molecules/metabolism
- Cytoskeleton/metabolism
- Humans
- Leukocytes/cytology
- Lymphocyte Function-Associated Antigen-1/metabolism