TY - JOUR
T1 - Baroreflex sensitivity is higher during acute psychological stress in healthy subjects under β-adrenergic blockade
AU - Truijen, Jasper
AU - Davis, Shyrin C. A. T.
AU - Stok, Wim J.
AU - Kim, Yu-Sok
AU - van Westerloo, David J.
AU - Levi, Marcel
AU - van der Poll, Tom
AU - Westerhof, Berend E.
AU - Karemaker, John M.
AU - van Lieshout, Johannes J.
PY - 2011/2
Y1 - 2011/2
N2 - Acute psychological stress challenges the cardiovascular system with an increase in BP (blood pressure), HR (heart rate) and reduced BRS (baroreflex sensitivity). β-adrenergic blockade enhances BRS during rest, but its effect on BRS during acute psychological stress is unknown. This study tested the hypothesis that BRS is higher during acute psychological stress in healthy subjects under β-adrenergic blockade. Twenty healthy novice male bungee jumpers were randomized and studied with (PROP, n=10) or without (CTRL, n=10) propranolol. BP and HR responses and BRS [cross-correlation time-domain (BRSTD) and cross-spectral frequency-domain (BRSFD) analysis] were evaluated from 30 min prior up to 2 h after the jump. HR, cardiac output and pulse pressure were lower in the PROP group throughout the study. Prior to the bungee jump, BRS was higher in the PROP group compared with the CTRL group [BRSTD: 28 (24-42) compared with 17 (16-28) ms·mmHg-1, P <0.05; BRSFD: 27 (20-34) compared with 14 (9-19) ms·mmHg-1, P <0.05; values are medians (interquartile range)]. BP declined after the jump in both groups, and post-jump BRS did not differ between the groups. In conclusion, during acute psychological stress, BRS is higher in healthy subjects treated with non-selective β-adrenergic blockade with significantly lower HR but comparable BP
AB - Acute psychological stress challenges the cardiovascular system with an increase in BP (blood pressure), HR (heart rate) and reduced BRS (baroreflex sensitivity). β-adrenergic blockade enhances BRS during rest, but its effect on BRS during acute psychological stress is unknown. This study tested the hypothesis that BRS is higher during acute psychological stress in healthy subjects under β-adrenergic blockade. Twenty healthy novice male bungee jumpers were randomized and studied with (PROP, n=10) or without (CTRL, n=10) propranolol. BP and HR responses and BRS [cross-correlation time-domain (BRSTD) and cross-spectral frequency-domain (BRSFD) analysis] were evaluated from 30 min prior up to 2 h after the jump. HR, cardiac output and pulse pressure were lower in the PROP group throughout the study. Prior to the bungee jump, BRS was higher in the PROP group compared with the CTRL group [BRSTD: 28 (24-42) compared with 17 (16-28) ms·mmHg-1, P <0.05; BRSFD: 27 (20-34) compared with 14 (9-19) ms·mmHg-1, P <0.05; values are medians (interquartile range)]. BP declined after the jump in both groups, and post-jump BRS did not differ between the groups. In conclusion, during acute psychological stress, BRS is higher in healthy subjects treated with non-selective β-adrenergic blockade with significantly lower HR but comparable BP
KW - Acute Disease
KW - Adrenergic beta-Antagonists/pharmacology
KW - Adult
KW - Baroreflex/drug effects
KW - Blood Pressure/physiology
KW - Heart Rate/physiology
KW - Humans
KW - Male
KW - Propranolol/pharmacology
KW - Stress, Psychological/physiopathology
KW - Young Adult
U2 - https://doi.org/10.1042/CS20100137
DO - https://doi.org/10.1042/CS20100137
M3 - Article
C2 - 20828371
SN - 0143-5221
VL - 120
SP - 161
EP - 167
JO - Clinical science (London, England
JF - Clinical science (London, England
IS - 4
ER -