BCR-ABL1 Compound Mutations Combining Key Kinase Domain Positions Confer Clinical Resistance to Ponatinib in Ph Chromosome-Positive Leukemia

M.S. Zabriskie; C.A. Eide; S.K. Tantravahi; N.A. Vellore; J. Estrada; F.E. Nicolini; H.J. Khoury; R.A. Larson; M. Konopleva; J.E. Cortes; H. Kantarjian; E.J. Jabbour; S.M. Kornblau; J.H. Lipton; D. Rea; L. Stenke; G. Barbany; T. de Lange; J.C. Hernandez-Boluda; G.J. Ossenkoppele; R.D. Press; C. Chuah; S.L. Goldberg; M. Wetzler; F.X. Mahon; G. Etienne; M. Baccarani; S. Soverini; G. Rosti; P. Rousselot; R. Friedman; M. Deininger; K.R. Reynolds; W.L. Heaton; A.M. Eiring; A.D. Pomicter; J.S. Khorashad; T.W. Kelley; R. Baron; B.J. Druker; M.W. Deininger; T. O'Hare

doi:https://doi.org/10.1016/j.ccr.2014.07.006

BCR-ABL1 Compound Mutations Combining Key Kinase Domain Positions Confer Clinical Resistance to Ponatinib in Ph Chromosome-Positive Leukemia

M.S. Zabriskie, C.A. Eide, S.K. Tantravahi, N.A. Vellore, J. Estrada, F.E. Nicolini, H.J. Khoury, R.A. Larson, M. Konopleva, J.E. Cortes, H. Kantarjian, E.J. Jabbour, S.M. Kornblau, J.H. Lipton, D. Rea, L. Stenke, G. Barbany, T. de Lange, J.C. Hernandez-Boluda, G.J. OssenkoppeleR.D. Press, C. Chuah, S.L. Goldberg, M. Wetzler, F.X. Mahon, G. Etienne, M. Baccarani, S. Soverini, G. Rosti, P. Rousselot, R. Friedman, M. Deininger, K.R. Reynolds, W.L. Heaton, A.M. Eiring, A.D. Pomicter, J.S. Khorashad, T.W. Kelley, R. Baron, B.J. Druker, M.W. Deininger, T. O'Hare

Hematology (VUmc)

Research output: Contribution to journal › Article › Academic › peer-review

265 Citations (Scopus)

Original language	Undefined/Unknown
Pages (from-to)	428-442
Journal	Cancer cell
Volume	26
Issue number	3
DOIs	https://doi.org/10.1016/j.ccr.2014.07.006
Publication status	Published - 2014

Access to Document

https://doi.org/10.1016/j.ccr.2014.07.006

Cite this

Zabriskie, M. S., Eide, C. A., Tantravahi, S. K., Vellore, N. A., Estrada, J., Nicolini, F. E., Khoury, H. J., Larson, R. A., Konopleva, M., Cortes, J. E., Kantarjian, H., Jabbour, E. J., Kornblau, S. M., Lipton, J. H., Rea, D., Stenke, L., Barbany, G., de Lange, T., Hernandez-Boluda, J. C., ... O'Hare, T. (2014). BCR-ABL1 Compound Mutations Combining Key Kinase Domain Positions Confer Clinical Resistance to Ponatinib in Ph Chromosome-Positive Leukemia. Cancer cell, 26(3), 428-442. https://doi.org/10.1016/j.ccr.2014.07.006

@article{4fb3810994d3489ca32becdb668b8095,

title = "BCR-ABL1 Compound Mutations Combining Key Kinase Domain Positions Confer Clinical Resistance to Ponatinib in Ph Chromosome-Positive Leukemia",

author = "M.S. Zabriskie and C.A. Eide and S.K. Tantravahi and N.A. Vellore and J. Estrada and F.E. Nicolini and H.J. Khoury and R.A. Larson and M. Konopleva and J.E. Cortes and H. Kantarjian and E.J. Jabbour and S.M. Kornblau and J.H. Lipton and D. Rea and L. Stenke and G. Barbany and {de Lange}, T. and J.C. Hernandez-Boluda and G.J. Ossenkoppele and R.D. Press and C. Chuah and S.L. Goldberg and M. Wetzler and F.X. Mahon and G. Etienne and M. Baccarani and S. Soverini and G. Rosti and P. Rousselot and R. Friedman and M. Deininger and K.R. Reynolds and W.L. Heaton and A.M. Eiring and A.D. Pomicter and J.S. Khorashad and T.W. Kelley and R. Baron and B.J. Druker and M.W. Deininger and T. O'Hare",

year = "2014",

doi = "https://doi.org/10.1016/j.ccr.2014.07.006",

language = "Undefined/Unknown",

volume = "26",

pages = "428--442",

journal = "Cancer cell",

issn = "1535-6108",

publisher = "Cell Press",

number = "3",

}

Zabriskie, MS, Eide, CA, Tantravahi, SK, Vellore, NA, Estrada, J, Nicolini, FE, Khoury, HJ, Larson, RA, Konopleva, M, Cortes, JE, Kantarjian, H, Jabbour, EJ, Kornblau, SM, Lipton, JH, Rea, D, Stenke, L, Barbany, G, de Lange, T, Hernandez-Boluda, JC, Ossenkoppele, GJ, Press, RD, Chuah, C, Goldberg, SL, Wetzler, M, Mahon, FX, Etienne, G, Baccarani, M, Soverini, S, Rosti, G, Rousselot, P, Friedman, R, Deininger, M, Reynolds, KR, Heaton, WL, Eiring, AM, Pomicter, AD, Khorashad, JS, Kelley, TW, Baron, R, Druker, BJ, Deininger, MW & O'Hare, T 2014, 'BCR-ABL1 Compound Mutations Combining Key Kinase Domain Positions Confer Clinical Resistance to Ponatinib in Ph Chromosome-Positive Leukemia', Cancer cell, vol. 26, no. 3, pp. 428-442. https://doi.org/10.1016/j.ccr.2014.07.006

TY - JOUR

T1 - BCR-ABL1 Compound Mutations Combining Key Kinase Domain Positions Confer Clinical Resistance to Ponatinib in Ph Chromosome-Positive Leukemia

AU - Zabriskie, M.S.

AU - Eide, C.A.

AU - Tantravahi, S.K.

AU - Vellore, N.A.

AU - Estrada, J.

AU - Nicolini, F.E.

AU - Khoury, H.J.

AU - Larson, R.A.

AU - Konopleva, M.

AU - Cortes, J.E.

AU - Kantarjian, H.

AU - Jabbour, E.J.

AU - Kornblau, S.M.

AU - Lipton, J.H.

AU - Rea, D.

AU - Stenke, L.

AU - Barbany, G.

AU - de Lange, T.

AU - Hernandez-Boluda, J.C.

AU - Ossenkoppele, G.J.

AU - Press, R.D.

AU - Chuah, C.

AU - Goldberg, S.L.

AU - Wetzler, M.

AU - Mahon, F.X.

AU - Etienne, G.

AU - Baccarani, M.

AU - Soverini, S.

AU - Rosti, G.

AU - Rousselot, P.

AU - Friedman, R.

AU - Deininger, M.

AU - Reynolds, K.R.

AU - Heaton, W.L.

AU - Eiring, A.M.

AU - Pomicter, A.D.

AU - Khorashad, J.S.

AU - Kelley, T.W.

AU - Baron, R.

AU - Druker, B.J.

AU - Deininger, M.W.

AU - O'Hare, T.

PY - 2014

Y1 - 2014

U2 - https://doi.org/10.1016/j.ccr.2014.07.006

DO - https://doi.org/10.1016/j.ccr.2014.07.006

M3 - Article

C2 - 25132497

SN - 1535-6108

VL - 26

SP - 428

EP - 442

JO - Cancer cell

JF - Cancer cell

IS - 3

ER -