TY - JOUR
T1 - Bee- And Wasp-Venom Sensitization in Schoolchildren of High- And Low-Socioeconomic Status Living in an Urban Area of Indonesia
AU - Amaruddin, Aldian I.
AU - Koopman, Jan Pieter R.
AU - Muhammad, Munawir
AU - Versteeg, Serge A.
AU - Wahyuni, Sitti
AU - van Ree, Ronald
AU - Yazdanbakhsh, Maria
AU - Hamid, Firdaus
AU - Sartono, Erliyani
N1 - Funding Information: This work was supported by The Ministry of Research and Technology/National Research and Innovation Agency of The Republic of Indonesia (Kemenristek/BRIN) (Grants number: Ref: 7/ AMD/E1/KP. PTNBH/2020 to F.H.) and Leiden University Medical Center, The Netherlands. The sponsor of the study had no role in study design, data collection, data analysis, data interpretation, or writing of the report. Funding Information: This work was supported by The Ministry of Research and Technology/National Research and Innovation Agency of The Republic of Indonesia (Kemenristek/BRIN) (Grants number: Ref: 7/AMD/E1/KP. PTNBH/2020 to F.H.) and Leiden University Medical Center, The Netherlands. The sponsor of the study had no role in study design, data collection, data analysis, data interpretation, or writing of the report. Funding Information: The authors would like to thank all participants involved in this study as well as their parents, teachers, and headmasters and we also would like to thank our “IPHIC” field team for their tremendous efforts in sample collection. The authors would like to thank HUM-RC for providing laboratory facilities in the field, and local government and Hasanuddin University for the support. We thank the Joint Scholarship of Directorate General of Resources for Science Technology and Higher Education (DGRSTHE) of Indonesia and Leiden University for providing PhD scholarship to A.A. Publisher Copyright: © 2021 S. Karger AG. All rights reserved.
PY - 2021/11/1
Y1 - 2021/11/1
N2 - Background: There is not much known about venom allergy in tropical regions. Here, we studied the prevalence of specific IgE (sIgE) and skin prick test (SPT) reactivity and reported sting-related symptoms, in high- and low-socioeconomic status (SES) schoolchildren living in urban city of Makassar in Indonesia. Methods: Children from high- (n = 160) and low- (n = 165) SES schools were recruited. Standardized questionnaires were used to record information on allergic disorders as well as sting-related symptoms. Parasitic infection, SPT reactivity, and sIgE to Apis mellifera (bee-venom) as well as Vespula spp. (wasp-venom) were assessed. Results: SPT reactivity to bee- and wasp-venom was 14.3 and 12.7%, while the prevalence of sIgE was 26.5 and 28.5%, respectively. When SES was considered, prevalence of SPT to bee- and wasp-venom was higher in high-SES than in low-SES schoolchildren (bee: 22.8 vs. 5.7%, p < 0.001; and wasp: 19.6 vs. 5.7%, p < 0.001). Conversely, sIgE to both venoms was lower in high-SES than in low-SES (bee: 19 vs. 34%, p = 0.016; and wasp: 19 vs. 38%, p = 0.003). Furthermore, among SPT positive subjects, considerable proportion had no detectable sIgE to bee- (65.85%) or wasp-venom (66.67%). Altogether the sensitizations were rarely translated into clinical reaction, as only 1 child reported significant local reaction after being stung. No association with parasitic infections was found. Conclusions and Clinical Relevance: Sensitization against bee- or wasp-venom is quite prevalent among schoolchildren in Indonesia. The discordance between SPT and sIgE might suggest the direct (non-IgE) effect of venoms in skin reactivity. Recorded sensitizations had poor clinical relevance as they rarely translated into clinical symptoms.
AB - Background: There is not much known about venom allergy in tropical regions. Here, we studied the prevalence of specific IgE (sIgE) and skin prick test (SPT) reactivity and reported sting-related symptoms, in high- and low-socioeconomic status (SES) schoolchildren living in urban city of Makassar in Indonesia. Methods: Children from high- (n = 160) and low- (n = 165) SES schools were recruited. Standardized questionnaires were used to record information on allergic disorders as well as sting-related symptoms. Parasitic infection, SPT reactivity, and sIgE to Apis mellifera (bee-venom) as well as Vespula spp. (wasp-venom) were assessed. Results: SPT reactivity to bee- and wasp-venom was 14.3 and 12.7%, while the prevalence of sIgE was 26.5 and 28.5%, respectively. When SES was considered, prevalence of SPT to bee- and wasp-venom was higher in high-SES than in low-SES schoolchildren (bee: 22.8 vs. 5.7%, p < 0.001; and wasp: 19.6 vs. 5.7%, p < 0.001). Conversely, sIgE to both venoms was lower in high-SES than in low-SES (bee: 19 vs. 34%, p = 0.016; and wasp: 19 vs. 38%, p = 0.003). Furthermore, among SPT positive subjects, considerable proportion had no detectable sIgE to bee- (65.85%) or wasp-venom (66.67%). Altogether the sensitizations were rarely translated into clinical reaction, as only 1 child reported significant local reaction after being stung. No association with parasitic infections was found. Conclusions and Clinical Relevance: Sensitization against bee- or wasp-venom is quite prevalent among schoolchildren in Indonesia. The discordance between SPT and sIgE might suggest the direct (non-IgE) effect of venoms in skin reactivity. Recorded sensitizations had poor clinical relevance as they rarely translated into clinical symptoms.
KW - Developing country
KW - Epidemiology
KW - Pediatrics
KW - Urban
KW - Venom and insect allergy
UR - http://www.scopus.com/inward/record.url?scp=85105970864&partnerID=8YFLogxK
U2 - https://doi.org/10.1159/000516155
DO - https://doi.org/10.1159/000516155
M3 - Article
C2 - 33951631
SN - 1018-2438
VL - 182
SP - 1036
EP - 1045
JO - International archives of allergy and immunology
JF - International archives of allergy and immunology
IS - 11
ER -