TY - JOUR
T1 - Behavioral Circadian Timing System Disruptors and Incident Type 2 Diabetes in a Nonshift Working Multi-Ethnic Population
AU - Muilwijk, Mirthe
AU - Stenvers, Dirk Jan
AU - Nicolaou, Mary
AU - Kalsbeek, Andries
AU - van Valkengoed, Irene G. M.
N1 - Funding Information: The HELIUS study is conducted by the Academic Medical Center of Amsterdam and the Public Health Service of Amsterdam. Both organizations provided core support for HELIUS. The HELIUS study is also funded by the Dutch Heart Foundation, the Netherlands Organization for Health Research and Development (ZonMw), the European Union (FP‐7), and the European Fund for the Integration of non‐EU Immigrants (EIF). Publisher Copyright: © 2020 Amsterdam UMC. Obesity published by Wiley Periodicals LLC on behalf of The Obesity Society (TOS).
PY - 2020/7/1
Y1 - 2020/7/1
N2 - Objective: This study aimed to describe distributions of behavioral circadian disruptors in a free-living setting among a nonshift working multiethnic population, estimate the associated risk of type 2 diabetes (T2D), and determine whether disruptors account for ethnic differences in T2D. Methods: Participants from six ethnic groups were included (Amsterdam, the Netherlands; n = 1,347-3,077 per group). Multinomial logistic regression was used to estimate ethnic differences in disruptors, such as skipping breakfast, eating erratically, and sleep duration. Associations between disruptors and incident T2D and the interaction by ethnicity were studied by Cox regression. Results: Ethnic minority populations skipped breakfast more often, timed meals differently, had longer periods of fasting, ate more erratically, and had more short/long sleep durations than the Dutch. Night snacking from 4 am to 6 am (HR: 5.82; 95% CI: 1.42-23.91) and both short (HR: 1.48; 95% CI: 1.03-2.12) and long sleep (HR: 3.09; 95% CI: 1.54-6.22), but no other disruptors, were associated with T2D. The higher T2D risk among ethnic minority populations compared with Dutch did not decrease after adjustment for last snack or length of sleep. Conclusions: Although prevalence of circadian disruptors was higher among ethnic minority populations and some disruptors were associated with T2D, disruptors did not account for ethnic differences in T2D risk.
AB - Objective: This study aimed to describe distributions of behavioral circadian disruptors in a free-living setting among a nonshift working multiethnic population, estimate the associated risk of type 2 diabetes (T2D), and determine whether disruptors account for ethnic differences in T2D. Methods: Participants from six ethnic groups were included (Amsterdam, the Netherlands; n = 1,347-3,077 per group). Multinomial logistic regression was used to estimate ethnic differences in disruptors, such as skipping breakfast, eating erratically, and sleep duration. Associations between disruptors and incident T2D and the interaction by ethnicity were studied by Cox regression. Results: Ethnic minority populations skipped breakfast more often, timed meals differently, had longer periods of fasting, ate more erratically, and had more short/long sleep durations than the Dutch. Night snacking from 4 am to 6 am (HR: 5.82; 95% CI: 1.42-23.91) and both short (HR: 1.48; 95% CI: 1.03-2.12) and long sleep (HR: 3.09; 95% CI: 1.54-6.22), but no other disruptors, were associated with T2D. The higher T2D risk among ethnic minority populations compared with Dutch did not decrease after adjustment for last snack or length of sleep. Conclusions: Although prevalence of circadian disruptors was higher among ethnic minority populations and some disruptors were associated with T2D, disruptors did not account for ethnic differences in T2D risk.
KW - Adult
KW - Circadian Clocks/physiology
KW - Diabetes Mellitus, Type 2/epidemiology
KW - Ethnicity
KW - Female
KW - Humans
KW - Male
KW - Middle Aged
KW - Prevalence
KW - Risk Factors
UR - http://www.scopus.com/inward/record.url?scp=85084990467&partnerID=8YFLogxK
U2 - https://doi.org/10.1002/oby.22777
DO - https://doi.org/10.1002/oby.22777
M3 - Article
C2 - 32438513
SN - 1930-7381
VL - 28
SP - S55-S62
JO - Obesity (Silver Spring, Md.)
JF - Obesity (Silver Spring, Md.)
IS - S1
ER -