Abstract
Well-consolidated fear-related memories, once retrieved, are susceptible to disruption and require reconsolidation in order to be maintained. We examined whether reactivated reward-related memories are also susceptible to interference by evaluating the effect of propranolol (PROP), a beta-adrenergic antagonist known to impair reconsolidation of fear-related memories, on context-induced sucrose seeking. PROP administration upon reactivation reduced sucrose seeking behaviour 3 weeks post-training, indicating that reconsolidation of reward-related memories can be disrupted after a long post-training interval.
Original language | English |
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Pages (from-to) | 333-6 |
Number of pages | 4 |
Journal | Behavioural Brain Research |
Volume | 170 |
Issue number | 2 |
DOIs | |
Publication status | Published - 30 Jun 2006 |
Keywords
- Adrenergic beta-Antagonists
- Analysis of Variance
- Animals
- Behavior, Animal
- Comparative Study
- Inhibition (Psychology)
- Journal Article
- Male
- Memory
- Propranolol
- Rats
- Rats, Wistar
- Receptors, Adrenergic, beta
- Reward
- Time Factors