TY - JOUR
T1 - Beyond RECIST: molecular and functional imaging techniques for evaluation of response to targeted therapy
AU - Desar, I. M. E.
AU - van Herpen, C. M. L.
AU - van Laarhoven, H. W. M.
AU - Barentsz, J. O.
AU - Oyen, W. J. G.
AU - van der Graaf, W. T. A.
PY - 2009
Y1 - 2009
N2 - The development of targeted therapies is a major breakthrough in the treatment of cancer. By evoking necrosis and cavitation, evaluation based on tumour size alone, as is done in the RECIST criteria, is no longer an adequate method. New molecular and functional imaging techniques are developed. This review focuses on the use of new imaging modalities for the evaluation of treatment response of pathway based targeted therapies. First, the basic principles of functional and molecular imaging modalities are briefly discussed. Thereafter, their clinical application in targeted therapies is correlated to the underlying biological mechanism. In this way, the best method for response evaluation for a new agent can be identified
AB - The development of targeted therapies is a major breakthrough in the treatment of cancer. By evoking necrosis and cavitation, evaluation based on tumour size alone, as is done in the RECIST criteria, is no longer an adequate method. New molecular and functional imaging techniques are developed. This review focuses on the use of new imaging modalities for the evaluation of treatment response of pathway based targeted therapies. First, the basic principles of functional and molecular imaging modalities are briefly discussed. Thereafter, their clinical application in targeted therapies is correlated to the underlying biological mechanism. In this way, the best method for response evaluation for a new agent can be identified
U2 - https://doi.org/10.1016/j.ctrv.2008.12.001
DO - https://doi.org/10.1016/j.ctrv.2008.12.001
M3 - Review article
C2 - 19136215
SN - 0305-7372
VL - 35
SP - 309
EP - 321
JO - Cancer Treatment Reviews
JF - Cancer Treatment Reviews
IS - 4
ER -