TY - JOUR
T1 - Biogenesis and function of extracellular vesicles in cancer
AU - Bebelman, Maarten P.
AU - Smit, Martine J.
AU - Pegtel, D. Michiel
AU - Baglio, S. Rubina
PY - 2018/8/1
Y1 - 2018/8/1
N2 - Extracellular vesicles (EVs) are heterogeneous multi-signal messengers that support cancer growth and dissemination by mediating the tumor-stroma crosstalk. Exosomes are a subtype of EVs that originate from the limiting membrane of late endosomes, and as such contain information linked to both the intrinsic cell “state” and the extracellular signals cells received from their environment. Resolving the signals affecting exosome biogenesis, cargo sorting and release will increase our understanding of tumorigenesis. In this review we highlight key cell biological processes that couple exosome biogenesis to cargo sorting in cancer cells. Moreover, we discuss how the bidirectional communication between tumor and non-malignant cells affect cancer growth and metastatic behavior.
AB - Extracellular vesicles (EVs) are heterogeneous multi-signal messengers that support cancer growth and dissemination by mediating the tumor-stroma crosstalk. Exosomes are a subtype of EVs that originate from the limiting membrane of late endosomes, and as such contain information linked to both the intrinsic cell “state” and the extracellular signals cells received from their environment. Resolving the signals affecting exosome biogenesis, cargo sorting and release will increase our understanding of tumorigenesis. In this review we highlight key cell biological processes that couple exosome biogenesis to cargo sorting in cancer cells. Moreover, we discuss how the bidirectional communication between tumor and non-malignant cells affect cancer growth and metastatic behavior.
KW - Cargo sorting
KW - Exosome biogenesis
KW - Extracellular vesicles
KW - Tumor microenvironment
KW - Tumor-stroma communication
UR - https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85042858674&origin=inward
UR - https://www.ncbi.nlm.nih.gov/pubmed/29476772
UR - http://www.mendeley.com/research/biogenesis-function-extracellular-vesicles-cancer
UR - http://www.scopus.com/inward/record.url?scp=85042858674&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85042858674&partnerID=8YFLogxK
U2 - https://doi.org/10.1016/j.pharmthera.2018.02.013
DO - https://doi.org/10.1016/j.pharmthera.2018.02.013
M3 - Review article
C2 - 29476772
SN - 0163-7258
VL - 188
SP - 1
EP - 11
JO - Pharmacology & Therapeutics
JF - Pharmacology & Therapeutics
ER -
