TY - JOUR
T1 - Biological mechanisms implicated in adverse outcomes of sex mismatched transfusions
AU - Alshalani, Abdulrahman
AU - Li, Wenhui
AU - Juffermans, Nicole P.
AU - Seghatchian, Jerard
AU - Acker, Jason P.
N1 - Copyright © 2019 Elsevier Ltd. All rights reserved.
PY - 2019/6
Y1 - 2019/6
N2 - Transfusion of red cell concentrates is an essential lifesaving treatment for patients with massive bleeding or red blood cell disorders. However, correlations between blood transfusion from female donors, especially in sex mismatched transfusions, and a risk of mortality has been reported. A systematic understanding of how sex-mismatched transfusion can contribute to negative outcomes is still lacking. Here, we propose that variations in stored red blood cell products from female and male blood donors may be related to different characteristics of subpopulations of RBCs in units. As very little attention has been paid to this topic, the aim of this review is to investigate biological mechanisms implicated in negative outcomes of sex-mismatched transfusion. This review discusses basic hematology differences in the blood from female and male donors. Also, observational studies that linked donor sex with adverse transfusion outcome are reviewed. We present three physiological mechanisms (oxygen delivery, coagulation and microvesiculation) that could be impacted by sex-mismatched transfusions.
AB - Transfusion of red cell concentrates is an essential lifesaving treatment for patients with massive bleeding or red blood cell disorders. However, correlations between blood transfusion from female donors, especially in sex mismatched transfusions, and a risk of mortality has been reported. A systematic understanding of how sex-mismatched transfusion can contribute to negative outcomes is still lacking. Here, we propose that variations in stored red blood cell products from female and male blood donors may be related to different characteristics of subpopulations of RBCs in units. As very little attention has been paid to this topic, the aim of this review is to investigate biological mechanisms implicated in negative outcomes of sex-mismatched transfusion. This review discusses basic hematology differences in the blood from female and male donors. Also, observational studies that linked donor sex with adverse transfusion outcome are reviewed. We present three physiological mechanisms (oxygen delivery, coagulation and microvesiculation) that could be impacted by sex-mismatched transfusions.
UR - https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85064967345&origin=inward
UR - https://www.ncbi.nlm.nih.gov/pubmed/31064732
U2 - https://doi.org/10.1016/j.transci.2019.04.023
DO - https://doi.org/10.1016/j.transci.2019.04.023
M3 - Review article
C2 - 31064732
SN - 1473-0502
VL - 58
SP - 351
EP - 356
JO - Transfusion and apheresis science : official journal of the World Apheresis Association
JF - Transfusion and apheresis science : official journal of the World Apheresis Association
IS - 3
ER -