TY - JOUR
T1 - Biomedical Applications of Photo- and Sono-Activated Rose Bengal: A Review
AU - Vanerio, Noemi
AU - Stijnen, Marco
AU - de Mol, Bas A. J. M.
AU - Kock, Linda M.
PY - 2019
Y1 - 2019
N2 - Objective: The aim of this review is to discuss and compare the extensive range of biomedical applications of photo- and sono-activated Rose Bengal (RB). Background data: RB is a xanthene dye that due to its interesting photo- and sono-sensitive properties is gaining attention in the scientific field. Methods: This study is a literature review using the database PubMed. Results: As a photosensitizer, RB converts the triplet oxygen molecule into reactive oxygen species after irradiation with green light (532 nm). This mechanism allows for the use of photo-activated RB in photochemical tissue bonding, photodynamic therapy, antimicrobial therapy and cancer treatment, photothrombotic animal models, and other applications, including tissue engineering and treatment of tauopathies. As a sono-sensitive compound, RB is applied for sonodynamic therapy, cancer treatment, and antimicrobial therapy. Conclusions: This review outlines the versatility and effectiveness of photo- and sono-activated RB in numerous biomedical applications.
AB - Objective: The aim of this review is to discuss and compare the extensive range of biomedical applications of photo- and sono-activated Rose Bengal (RB). Background data: RB is a xanthene dye that due to its interesting photo- and sono-sensitive properties is gaining attention in the scientific field. Methods: This study is a literature review using the database PubMed. Results: As a photosensitizer, RB converts the triplet oxygen molecule into reactive oxygen species after irradiation with green light (532 nm). This mechanism allows for the use of photo-activated RB in photochemical tissue bonding, photodynamic therapy, antimicrobial therapy and cancer treatment, photothrombotic animal models, and other applications, including tissue engineering and treatment of tauopathies. As a sono-sensitive compound, RB is applied for sonodynamic therapy, cancer treatment, and antimicrobial therapy. Conclusions: This review outlines the versatility and effectiveness of photo- and sono-activated RB in numerous biomedical applications.
UR - https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85068477894&origin=inward
UR - https://www.ncbi.nlm.nih.gov/pubmed/31180251
U2 - https://doi.org/10.1089/photob.2018.4604
DO - https://doi.org/10.1089/photob.2018.4604
M3 - Article
C2 - 31180251
SN - 2578-5478
VL - 37
SP - 383
EP - 394
JO - Photobiomodulation, Photomedicine, and Laser Surgery
JF - Photobiomodulation, Photomedicine, and Laser Surgery
IS - 7
ER -