TY - JOUR
T1 - Bone invasion by oral squamous cell carcinoma—Is there a link to periodontal disease? A retrospective single center cohort study
T2 - 2010–2020
AU - Vaassen, Lauretta A. A.
AU - Suhr, Mara M.
AU - Hagens, Eliza R. C.
AU - Speel, Ernst-Jan M.
AU - Kessler, Peter A. W. H.
N1 - Publisher Copyright: © 2023 The Authors
PY - 2023/12/1
Y1 - 2023/12/1
N2 - Objectives: The aim of this study was to clarify if bone invasion by oral squamous cell carcinoma (OSCC) is associated with periodontal disease (PD), dental status, or tumor location in patients with primary OSCC. Additional overall survival (OS) and recurrence-free survival (RFS) were related to bone invasion and PD. Patients and methods: Retrospectively, 278 patients with OSCC between 2010 and 2020 were included. Uni- and multivariate analyses were performed to assess the association between PD, dental status, tumor location, and the presence of bone invasion by OSCC. Kaplan-Meier curves and logrank tests were used to assess differences in 5-year OS and RFS for the presence of bone invasion and PD. Results: In dentate patients (n = 168) periodontal disease was more common in patients with bone-invasive OSCC (90%) compared to patients without OSCC bone invasion (70%), (p = 0.009; OR 3.7 (1.4–9.0)). Floor of mouth (FOM) tumors are more frequent when PD was present (41%). No statistically significant difference was seen in dental status and bone invasion (p = 0.10). Moderate periodontitis was associated with worse OS (55%) compared to severe and no periodontitis (67% and 68% respectively) (p = 0.03; mean survival 42.7 months (SD26.5)). Favorable OS and RFS were significantly associated with no bone invasion (p = 0.047 and 0.035 respectively). Conclusion: PD is 3.7 times more common in OSCC with bone invasion and tumor location is related to PD (p < 0.0001). Thus, periodontitis could be a risk factor for bone-invasive OSCC. Elimination of PD might lead to higher OS.
AB - Objectives: The aim of this study was to clarify if bone invasion by oral squamous cell carcinoma (OSCC) is associated with periodontal disease (PD), dental status, or tumor location in patients with primary OSCC. Additional overall survival (OS) and recurrence-free survival (RFS) were related to bone invasion and PD. Patients and methods: Retrospectively, 278 patients with OSCC between 2010 and 2020 were included. Uni- and multivariate analyses were performed to assess the association between PD, dental status, tumor location, and the presence of bone invasion by OSCC. Kaplan-Meier curves and logrank tests were used to assess differences in 5-year OS and RFS for the presence of bone invasion and PD. Results: In dentate patients (n = 168) periodontal disease was more common in patients with bone-invasive OSCC (90%) compared to patients without OSCC bone invasion (70%), (p = 0.009; OR 3.7 (1.4–9.0)). Floor of mouth (FOM) tumors are more frequent when PD was present (41%). No statistically significant difference was seen in dental status and bone invasion (p = 0.10). Moderate periodontitis was associated with worse OS (55%) compared to severe and no periodontitis (67% and 68% respectively) (p = 0.03; mean survival 42.7 months (SD26.5)). Favorable OS and RFS were significantly associated with no bone invasion (p = 0.047 and 0.035 respectively). Conclusion: PD is 3.7 times more common in OSCC with bone invasion and tumor location is related to PD (p < 0.0001). Thus, periodontitis could be a risk factor for bone-invasive OSCC. Elimination of PD might lead to higher OS.
KW - Bone invasion
KW - Chronic infection
KW - Oral cancer
KW - Periodontal disease
KW - Squamous cell carcinoma
UR - http://www.scopus.com/inward/record.url?scp=85180933417&partnerID=8YFLogxK
U2 - https://doi.org/10.1016/j.oor.2023.100108
DO - https://doi.org/10.1016/j.oor.2023.100108
M3 - Article
SN - 2772-9060
VL - 8
JO - Oral Oncology Reports
JF - Oral Oncology Reports
M1 - 100108
ER -