TY - JOUR
T1 - Bone muscle interactions and vitamin D
AU - Gunton, J.E.
AU - Girgis, C.M.
AU - Baldock, P.A.
AU - Lips, P.
PY - 2015
Y1 - 2015
N2 - Beyond the established roles of vitamin D in bone and mineral homeostasis, we are becoming increasingly aware of its diverse effects in skeletal muscle. Subjects with severe vitamin D deficiency or mutations of the vitamin D receptor develop generalized atrophy of muscle and bone, suggesting coordinated effects of vitamin D in musculoskeletal physiology. At a mechanistic level, vitamin D exerts wide-ranging effects in muscle and bone calcium handling, differentiation and development. Vitamin D also modulates muscle and bone-derived hormones, facilitating cross-talk between these tissues. In this review, we discuss emerging evidence that vitamin D regulates bone and muscle in a direct, integrated fashion, positioning the vitamin D pathway as a potential therapeutic target for musculoskeletal diseases.This article is part of a Special Issue entitled "Muscle Bone Interactions".
AB - Beyond the established roles of vitamin D in bone and mineral homeostasis, we are becoming increasingly aware of its diverse effects in skeletal muscle. Subjects with severe vitamin D deficiency or mutations of the vitamin D receptor develop generalized atrophy of muscle and bone, suggesting coordinated effects of vitamin D in musculoskeletal physiology. At a mechanistic level, vitamin D exerts wide-ranging effects in muscle and bone calcium handling, differentiation and development. Vitamin D also modulates muscle and bone-derived hormones, facilitating cross-talk between these tissues. In this review, we discuss emerging evidence that vitamin D regulates bone and muscle in a direct, integrated fashion, positioning the vitamin D pathway as a potential therapeutic target for musculoskeletal diseases.This article is part of a Special Issue entitled "Muscle Bone Interactions".
U2 - https://doi.org/10.1016/j.bone.2015.02.029
DO - https://doi.org/10.1016/j.bone.2015.02.029
M3 - Article
C2 - 25745883
SN - 8756-3282
VL - 80
SP - 89
EP - 94
JO - Bone
JF - Bone
ER -