Both overexpression of agouti-related peptide or neuropeptide Y in the paraventricular nucleus or lateral hypothalamus induce obesity in a neuropeptide- and nucleus specific manner

Marijke W. A. de Backer; Susanne E. la Fleur; Roger A. H. Adan

doi:https://doi.org/10.1016/j.ejphar.2010.12.021

Both overexpression of agouti-related peptide or neuropeptide Y in the paraventricular nucleus or lateral hypothalamus induce obesity in a neuropeptide- and nucleus specific manner

Marijke W. A. de Backer, Susanne E. la Fleur, Roger A. H. Adan

Research output: Contribution to journal › Review article › Academic › peer-review

6 Citations (Scopus)

Abstract

Both reduction of melanocortin signaling and increase in neuropeptide Y signaling in the brain result in obesity. However, where in the brain reduced melanocortin or increased neuropeptide Y signaling mediate these effects is poorly understood. In separate experiments we have injected recombinant adeno-associated viral vectors that overexpressed agouti-related peptide or neuropeptide Y in specific brain regions namely the paraventricular nucleus and the lateral hypothalamus. In this review we compare the results from these studies and discuss these data with previous data from intracerebroventricular or local brain injections. This review shows that the effects of agouti-related peptide clearly differ from those of neuropeptide Y. In addition, these data suggests complementary roles for these neuropeptides in energy balance

Original language	English
Pages (from-to)	148-155
Journal	European journal of pharmacology
Volume	660
Issue number	1
DOIs	https://doi.org/10.1016/j.ejphar.2010.12.021
Publication status	Published - 2011

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https://doi.org/10.1016/j.ejphar.2010.12.021

Cite this

@article{e57fc5ce5cd14c86949f252a73e45ce4,

title = "Both overexpression of agouti-related peptide or neuropeptide Y in the paraventricular nucleus or lateral hypothalamus induce obesity in a neuropeptide- and nucleus specific manner",

abstract = "Both reduction of melanocortin signaling and increase in neuropeptide Y signaling in the brain result in obesity. However, where in the brain reduced melanocortin or increased neuropeptide Y signaling mediate these effects is poorly understood. In separate experiments we have injected recombinant adeno-associated viral vectors that overexpressed agouti-related peptide or neuropeptide Y in specific brain regions namely the paraventricular nucleus and the lateral hypothalamus. In this review we compare the results from these studies and discuss these data with previous data from intracerebroventricular or local brain injections. This review shows that the effects of agouti-related peptide clearly differ from those of neuropeptide Y. In addition, these data suggests complementary roles for these neuropeptides in energy balance",

author = "{de Backer}, {Marijke W. A.} and {la Fleur}, {Susanne E.} and Adan, {Roger A. H.}",

year = "2011",

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language = "English",

volume = "660",

pages = "148--155",

journal = "European journal of pharmacology",

issn = "0014-2999",

publisher = "Elsevier",

number = "1",

}

Both overexpression of agouti-related peptide or neuropeptide Y in the paraventricular nucleus or lateral hypothalamus induce obesity in a neuropeptide- and nucleus specific manner. / de Backer, Marijke W. A.; la Fleur, Susanne E.; Adan, Roger A. H.
In: European journal of pharmacology, Vol. 660, No. 1, 2011, p. 148-155.

Research output: Contribution to journal › Review article › Academic › peer-review

TY - JOUR

T1 - Both overexpression of agouti-related peptide or neuropeptide Y in the paraventricular nucleus or lateral hypothalamus induce obesity in a neuropeptide- and nucleus specific manner

AU - de Backer, Marijke W. A.

AU - la Fleur, Susanne E.

AU - Adan, Roger A. H.

PY - 2011

Y1 - 2011

N2 - Both reduction of melanocortin signaling and increase in neuropeptide Y signaling in the brain result in obesity. However, where in the brain reduced melanocortin or increased neuropeptide Y signaling mediate these effects is poorly understood. In separate experiments we have injected recombinant adeno-associated viral vectors that overexpressed agouti-related peptide or neuropeptide Y in specific brain regions namely the paraventricular nucleus and the lateral hypothalamus. In this review we compare the results from these studies and discuss these data with previous data from intracerebroventricular or local brain injections. This review shows that the effects of agouti-related peptide clearly differ from those of neuropeptide Y. In addition, these data suggests complementary roles for these neuropeptides in energy balance

AB - Both reduction of melanocortin signaling and increase in neuropeptide Y signaling in the brain result in obesity. However, where in the brain reduced melanocortin or increased neuropeptide Y signaling mediate these effects is poorly understood. In separate experiments we have injected recombinant adeno-associated viral vectors that overexpressed agouti-related peptide or neuropeptide Y in specific brain regions namely the paraventricular nucleus and the lateral hypothalamus. In this review we compare the results from these studies and discuss these data with previous data from intracerebroventricular or local brain injections. This review shows that the effects of agouti-related peptide clearly differ from those of neuropeptide Y. In addition, these data suggests complementary roles for these neuropeptides in energy balance

U2 - https://doi.org/10.1016/j.ejphar.2010.12.021

DO - https://doi.org/10.1016/j.ejphar.2010.12.021

M3 - Review article

C2 - 21211526

SN - 0014-2999

VL - 660

SP - 148

EP - 155

JO - European journal of pharmacology

JF - European journal of pharmacology

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