Brain-Area Specific White Matter Hyperintensities: Associations to Falls in Parkinson's Disease

Meltem Ciliz; Jennifer Sartor; Tobias Lindig; Andrea Pilotto; Eva Schäffer; Michael Weiss; Philip Scheltens; Sara Becker; Markus A Hobert; Daniela Berg; Inga Liepelt-Scarfone; Walter Maetzler

doi:https://doi.org/10.3233/JPD-181351

Brain-Area Specific White Matter Hyperintensities: Associations to Falls in Parkinson's Disease

Meltem Ciliz, Jennifer Sartor, Tobias Lindig, Andrea Pilotto, Eva Schäffer, Michael Weiss, Philip Scheltens, Sara Becker, Markus A Hobert, Daniela Berg, Inga Liepelt-Scarfone, Walter Maetzler

Research output: Contribution to journal › Article › Academic › peer-review

6 Citations (Scopus)

Abstract

BACKGROUND: Falls are common among people with idiopathic Parkinson's disease (IPD) and are suggested to be associated with white matter hyperintensities (WMH) of the brain.

OBJECTIVE: To investigate the contribution of brain area-specific WMH to the risk of falls in IPD.

METHODS: In fifty participants with IPD, occurrence and severity of WMH in specific brain areas were determined using Scheltens (without lateralization) and Age-related white matter changes (ARWMC) (with lateralization) scores. Falls were evaluated with the fall item of the Unified PD Rating Scale (UPDRS). Correlations between area-specific WMH and falls were tested with stepwise backward regression and multivariate regression analyses.

RESULTS: In this cohort of participants with IPD, left temporal WMH were associated with occurrence of falls. Frontal WMH of both hemispheres showed tendencies towards significance for the association with falls.

CONCLUSION: According to our study, WMH in the left temporal area are significantly associated with falls in IPD. Potential reasons for this association could be deficits in memory, navigation, orientation, auditory processing, and fear conditioning, which are all associated with pathologies of the left temporal lobe.

Original language	English
Pages (from-to)	455-462
Number of pages	8
Journal	Journal of parkinsons disease
Volume	8
Issue number	3
DOIs	https://doi.org/10.3233/JPD-181351
Publication status	Published - 1 Jan 2018

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https://doi.org/10.3233/JPD-181351

Cite this

@article{09a3204b654040cea7bf5cae5054ce09,

title = "Brain-Area Specific White Matter Hyperintensities: Associations to Falls in Parkinson's Disease",

abstract = "BACKGROUND: Falls are common among people with idiopathic Parkinson's disease (IPD) and are suggested to be associated with white matter hyperintensities (WMH) of the brain.OBJECTIVE: To investigate the contribution of brain area-specific WMH to the risk of falls in IPD.METHODS: In fifty participants with IPD, occurrence and severity of WMH in specific brain areas were determined using Scheltens (without lateralization) and Age-related white matter changes (ARWMC) (with lateralization) scores. Falls were evaluated with the fall item of the Unified PD Rating Scale (UPDRS). Correlations between area-specific WMH and falls were tested with stepwise backward regression and multivariate regression analyses.RESULTS: In this cohort of participants with IPD, left temporal WMH were associated with occurrence of falls. Frontal WMH of both hemispheres showed tendencies towards significance for the association with falls.CONCLUSION: According to our study, WMH in the left temporal area are significantly associated with falls in IPD. Potential reasons for this association could be deficits in memory, navigation, orientation, auditory processing, and fear conditioning, which are all associated with pathologies of the left temporal lobe.",

author = "Meltem Ciliz and Jennifer Sartor and Tobias Lindig and Andrea Pilotto and Eva Sch{\"a}ffer and Michael Weiss and Philip Scheltens and Sara Becker and Hobert, {Markus A} and Daniela Berg and Inga Liepelt-Scarfone and Walter Maetzler",

year = "2018",

month = jan,

day = "1",

doi = "https://doi.org/10.3233/JPD-181351",

language = "English",

volume = "8",

pages = "455--462",

journal = "Journal of parkinsons disease",

issn = "1877-7171",

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number = "3",

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TY - JOUR

T1 - Brain-Area Specific White Matter Hyperintensities

T2 - Associations to Falls in Parkinson's Disease

AU - Ciliz, Meltem

AU - Sartor, Jennifer

AU - Lindig, Tobias

AU - Pilotto, Andrea

AU - Schäffer, Eva

AU - Weiss, Michael

AU - Scheltens, Philip

AU - Becker, Sara

AU - Hobert, Markus A

AU - Berg, Daniela

AU - Liepelt-Scarfone, Inga

AU - Maetzler, Walter

PY - 2018/1/1

Y1 - 2018/1/1

N2 - BACKGROUND: Falls are common among people with idiopathic Parkinson's disease (IPD) and are suggested to be associated with white matter hyperintensities (WMH) of the brain.OBJECTIVE: To investigate the contribution of brain area-specific WMH to the risk of falls in IPD.METHODS: In fifty participants with IPD, occurrence and severity of WMH in specific brain areas were determined using Scheltens (without lateralization) and Age-related white matter changes (ARWMC) (with lateralization) scores. Falls were evaluated with the fall item of the Unified PD Rating Scale (UPDRS). Correlations between area-specific WMH and falls were tested with stepwise backward regression and multivariate regression analyses.RESULTS: In this cohort of participants with IPD, left temporal WMH were associated with occurrence of falls. Frontal WMH of both hemispheres showed tendencies towards significance for the association with falls.CONCLUSION: According to our study, WMH in the left temporal area are significantly associated with falls in IPD. Potential reasons for this association could be deficits in memory, navigation, orientation, auditory processing, and fear conditioning, which are all associated with pathologies of the left temporal lobe.

AB - BACKGROUND: Falls are common among people with idiopathic Parkinson's disease (IPD) and are suggested to be associated with white matter hyperintensities (WMH) of the brain.OBJECTIVE: To investigate the contribution of brain area-specific WMH to the risk of falls in IPD.METHODS: In fifty participants with IPD, occurrence and severity of WMH in specific brain areas were determined using Scheltens (without lateralization) and Age-related white matter changes (ARWMC) (with lateralization) scores. Falls were evaluated with the fall item of the Unified PD Rating Scale (UPDRS). Correlations between area-specific WMH and falls were tested with stepwise backward regression and multivariate regression analyses.RESULTS: In this cohort of participants with IPD, left temporal WMH were associated with occurrence of falls. Frontal WMH of both hemispheres showed tendencies towards significance for the association with falls.CONCLUSION: According to our study, WMH in the left temporal area are significantly associated with falls in IPD. Potential reasons for this association could be deficits in memory, navigation, orientation, auditory processing, and fear conditioning, which are all associated with pathologies of the left temporal lobe.

U2 - https://doi.org/10.3233/JPD-181351

DO - https://doi.org/10.3233/JPD-181351

M3 - Article

C2 - 30040742

SN - 1877-7171

VL - 8

SP - 455

EP - 462

JO - Journal of parkinsons disease

JF - Journal of parkinsons disease

IS - 3

ER -