TY - JOUR
T1 - Brain atrophy and cognition
T2 - Interaction with cerebrovascular pathology?
AU - Muller, Majon
AU - Appelman, Auke P. A.
AU - van der Graaf, Yolanda
AU - Vincken, Koen L.
AU - Mali, Willem P. Th.M.
AU - Geerlings, Mirjam I.
PY - 2011/5
Y1 - 2011/5
N2 - We examined the interaction of brain atrophy and white matter lesions (WML) with cognitive functioning in 605 patients (mean age, 58 ± 10; 76% men) with atherosclerotic disease from the Second Manifestations of ARTerial disease-MR substudy (SMART-MR study). Automated brain segmentation was used to quantify volumes of brain tissue, cerebrospinal fluid, and WML on MRI. Total brain, ventricular, and cortical gray matter volume were divided by intracranial volume (ICV). Neuropsychological tests assessing executive functioning and memory performance were performed and composite scores were calculated. We observed that smaller total brain volume, larger ventricular volume, and smaller cortical gray matter volume (all as % of ICV) were associated with worse executive performance and that this association became stronger with presence of brain infarcts or severe WML volume (P-values for interaction <0.05). No interaction between measures of brain volume and cerebrovascular pathology on memory performance was observed. Our findings suggest that patients with cerebrovascular pathology on MRI may be more vulnerable to impairment in executive functioning related to global as well as focal brain atrophy. © 2009 Elsevier Inc.
AB - We examined the interaction of brain atrophy and white matter lesions (WML) with cognitive functioning in 605 patients (mean age, 58 ± 10; 76% men) with atherosclerotic disease from the Second Manifestations of ARTerial disease-MR substudy (SMART-MR study). Automated brain segmentation was used to quantify volumes of brain tissue, cerebrospinal fluid, and WML on MRI. Total brain, ventricular, and cortical gray matter volume were divided by intracranial volume (ICV). Neuropsychological tests assessing executive functioning and memory performance were performed and composite scores were calculated. We observed that smaller total brain volume, larger ventricular volume, and smaller cortical gray matter volume (all as % of ICV) were associated with worse executive performance and that this association became stronger with presence of brain infarcts or severe WML volume (P-values for interaction <0.05). No interaction between measures of brain volume and cerebrovascular pathology on memory performance was observed. Our findings suggest that patients with cerebrovascular pathology on MRI may be more vulnerable to impairment in executive functioning related to global as well as focal brain atrophy. © 2009 Elsevier Inc.
UR - https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=79954627120&origin=inward
UR - https://www.ncbi.nlm.nih.gov/pubmed/19520460
U2 - https://doi.org/10.1016/j.neurobiolaging.2009.05.005
DO - https://doi.org/10.1016/j.neurobiolaging.2009.05.005
M3 - Article
C2 - 19520460
SN - 0197-4580
VL - 32
SP - 885
EP - 893
JO - Neurobiology of aging
JF - Neurobiology of aging
IS - 5
ER -