Bridging the gap: from methodological developments towards clinical implementation of imaging biomarkers in lung and breast cancer

R. Iqbal

doi:https://doi.org/10.5463/thesis.292

Bridging the gap: from methodological developments towards clinical implementation of imaging biomarkers in lung and breast cancer

Research output: PhD Thesis › Phd-Thesis - Research and graduation internal

Abstract

PART I In chapter 2, the relationship between perfusion and hypoxia has been investigated with 15O-H2O en 18F-FAZA, respectively. In chapter 3 the relationship between perfusion and proliferation with 15O-H2O and 18F-FLT was investigated. PART II In chapter 4A and 4B, the biodistribution of 18F-FES has been described and it has been investigated how this is affected by rintodestrant, a novel SERD. In chapter 5 the pharmacokinetic profile of the 18F-FES radiotracer was investigated in patients with metastatic ER+ breast cancer. In chapter 6 it was investigated how the diagnostic accuracy is of 18F-FDG, the radiotracer that is currently used for staging of ER+ disease. In chapter 7, it was investigated how 18F-FDG versus 18F-FES heterogeneity predicts response to therapy and/or allows to monitor treatment effec

Original language	English
Qualification	Doctor of Philosophy
Awarding Institution	Vrije Universiteit Amsterdam
Supervisors/Advisors	Menke-van der Houven van Oordt, Willemien, Supervisor Boellaard, Ronald, Supervisor Verheul, H.M.W., Co-supervisor, External person Yaqub, Mohammed Maqsood, Co-supervisor Menke-van Der Houven Van Oordt, C.W., Supervisor, External person
Award date	12 Oct 2023
Print ISBNs	9789464731743
DOIs	https://doi.org/10.5463/thesis.292
Publication status	Published - 12 Oct 2023

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https://doi.org/10.5463/thesis.292

Cite this

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title = "Bridging the gap: from methodological developments towards clinical implementation of imaging biomarkers in lung and breast cancer",

abstract = "PART I In chapter 2, the relationship between perfusion and hypoxia has been investigated with 15O-H2O en 18F-FAZA, respectively. In chapter 3 the relationship between perfusion and proliferation with 15O-H2O and 18F-FLT was investigated. PART II In chapter 4A and 4B, the biodistribution of 18F-FES has been described and it has been investigated how this is affected by rintodestrant, a novel SERD. In chapter 5 the pharmacokinetic profile of the 18F-FES radiotracer was investigated in patients with metastatic ER+ breast cancer. In chapter 6 it was investigated how the diagnostic accuracy is of 18F-FDG, the radiotracer that is currently used for staging of ER+ disease. In chapter 7, it was investigated how 18F-FDG versus 18F-FES heterogeneity predicts response to therapy and/or allows to monitor treatment effec",

author = "R. Iqbal",

year = "2023",

month = oct,

day = "12",

doi = "https://doi.org/10.5463/thesis.292",

language = "English",

isbn = "9789464731743",

type = "Phd-Thesis - Research and graduation internal",

school = "Vrije Universiteit Amsterdam",

}

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T1 - Bridging the gap

T2 - from methodological developments towards clinical implementation of imaging biomarkers in lung and breast cancer

AU - Iqbal, R.

PY - 2023/10/12

Y1 - 2023/10/12

N2 - PART I In chapter 2, the relationship between perfusion and hypoxia has been investigated with 15O-H2O en 18F-FAZA, respectively. In chapter 3 the relationship between perfusion and proliferation with 15O-H2O and 18F-FLT was investigated. PART II In chapter 4A and 4B, the biodistribution of 18F-FES has been described and it has been investigated how this is affected by rintodestrant, a novel SERD. In chapter 5 the pharmacokinetic profile of the 18F-FES radiotracer was investigated in patients with metastatic ER+ breast cancer. In chapter 6 it was investigated how the diagnostic accuracy is of 18F-FDG, the radiotracer that is currently used for staging of ER+ disease. In chapter 7, it was investigated how 18F-FDG versus 18F-FES heterogeneity predicts response to therapy and/or allows to monitor treatment effec

AB - PART I In chapter 2, the relationship between perfusion and hypoxia has been investigated with 15O-H2O en 18F-FAZA, respectively. In chapter 3 the relationship between perfusion and proliferation with 15O-H2O and 18F-FLT was investigated. PART II In chapter 4A and 4B, the biodistribution of 18F-FES has been described and it has been investigated how this is affected by rintodestrant, a novel SERD. In chapter 5 the pharmacokinetic profile of the 18F-FES radiotracer was investigated in patients with metastatic ER+ breast cancer. In chapter 6 it was investigated how the diagnostic accuracy is of 18F-FDG, the radiotracer that is currently used for staging of ER+ disease. In chapter 7, it was investigated how 18F-FDG versus 18F-FES heterogeneity predicts response to therapy and/or allows to monitor treatment effec

U2 - https://doi.org/10.5463/thesis.292

DO - https://doi.org/10.5463/thesis.292

M3 - Phd-Thesis - Research and graduation internal

SN - 9789464731743

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