Brief Report: Anal Cancer in the HIV-Positive Population: Slowly Declining Incidence After a Decade of cART

Olivier Richel; Ramon P Van Der Zee; Colette Smit; Henry J C De Vries; Jan M Prins

doi:https://doi.org/10.1097/QAI.0000000000000675

Brief Report: Anal Cancer in the HIV-Positive Population: Slowly Declining Incidence After a Decade of cART

Olivier Richel, Ramon P Van Der Zee, Colette Smit, Henry J C De Vries, Jan M Prins

Research output: Contribution to journal › Article › Academic › peer-review

27 Citations (Scopus)

Abstract

We surveyed trends in incidence (1995-2012) and risk factors for anal cancer in the Dutch HIV-positive population. After an initial increase with a peak incidence in 2005-2006 of 114 [95% confidence interval (CI): 74 to 169] in all HIV+ patients and 168 (95% CI: 103 to 259) in HIV+ men who have sex with men (MSM), a decline to 72 (95% CI: 43 to 113) and 100 (95% CI: 56 to 164), respectively, was seen in 2011-2012. Low nadir CD4, alcohol use, and smoking were significantly associated with anal cancer in MSM. In conclusion, anal cancer remains a serious problem in predominantly HIV+ MSM. However, it seems that incidence rates are leveling off.

Original language	English
Pages (from-to)	602-5
Number of pages	4
Journal	JOURNAL OF ACQUIRED IMMUNE DEFICIENCY SYNDROMES
Volume	69
Issue number	5
DOIs	https://doi.org/10.1097/QAI.0000000000000675
Publication status	Published - 15 Aug 2015

Keywords

Adult
Alcoholism/complications
Anti-HIV Agents/administration & dosage
Anus Neoplasms/complications
CD4 Lymphocyte Count
Drug Therapy, Combination
Female
HIV Infections/complications
Homosexuality, Male
Humans
Incidence
Male
Middle Aged
Netherlands/epidemiology
Risk Factors
Smoking/adverse effects

Access to Document

https://doi.org/10.1097/QAI.0000000000000675

Cite this

@article{eda16409eaaf4bc38ead316bf627f402,

title = "Brief Report: Anal Cancer in the HIV-Positive Population: Slowly Declining Incidence After a Decade of cART",

abstract = "We surveyed trends in incidence (1995-2012) and risk factors for anal cancer in the Dutch HIV-positive population. After an initial increase with a peak incidence in 2005-2006 of 114 [95% confidence interval (CI): 74 to 169] in all HIV+ patients and 168 (95% CI: 103 to 259) in HIV+ men who have sex with men (MSM), a decline to 72 (95% CI: 43 to 113) and 100 (95% CI: 56 to 164), respectively, was seen in 2011-2012. Low nadir CD4, alcohol use, and smoking were significantly associated with anal cancer in MSM. In conclusion, anal cancer remains a serious problem in predominantly HIV+ MSM. However, it seems that incidence rates are leveling off. ",

keywords = "Adult, Alcoholism/complications, Anti-HIV Agents/administration & dosage, Anus Neoplasms/complications, CD4 Lymphocyte Count, Drug Therapy, Combination, Female, HIV Infections/complications, Homosexuality, Male, Humans, Incidence, Male, Middle Aged, Netherlands/epidemiology, Risk Factors, Smoking/adverse effects",

author = "Olivier Richel and {Van Der Zee}, {Ramon P} and Colette Smit and {De Vries}, {Henry J C} and Prins, {Jan M}",

year = "2015",

month = aug,

day = "15",

doi = "https://doi.org/10.1097/QAI.0000000000000675",

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AU - Smit, Colette

AU - De Vries, Henry J C

AU - Prins, Jan M

PY - 2015/8/15

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KW - Male

KW - Middle Aged

KW - Netherlands/epidemiology

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