TY - GEN
T1 - Burn Depth Determination by High-Speed Fiber-Based Polarization Sensitive Optical Coherence Tomography at 1.3 micrometers
AU - Park, B. Hyle
AU - Saxer, Chris
AU - Srinivas, Shyam M.
AU - Nelson, J. Stuart
AU - de Boer, Johannes F.
PY - 2002
Y1 - 2002
N2 - Burn depth determination is a critical factor in the treatment of thermal injury. We have developed a technique, polarization sensitive optical coherence tomography (PS-OCT), to assess burn depth non-invasively. Thermal injury denatures collagen in human skin. PS-OCT is able to measure the resulting reduction in collagen birefringence using depth resolved changes in the polarization of light propagated and reflected from the sample. In a previous study, we used a free space PS-OCT system at 850 nm to image in vivo the skin of rats burned for various amounts of time. Using a high-speed system at 1.3 micrometers has the advantages of greater depth penetration and reduction of motion artifacts due to breathing and small movements of the animal. Stokes vectors were calculated for each point in the scans and the relative birefringence was determined using different incident polarization states. Birefringence was correlated with actual burn depth determined by histological analysis. Our results show a marked difference between normal tissue and even the slightest burn, and a consistent trend for various degrees of burns.
AB - Burn depth determination is a critical factor in the treatment of thermal injury. We have developed a technique, polarization sensitive optical coherence tomography (PS-OCT), to assess burn depth non-invasively. Thermal injury denatures collagen in human skin. PS-OCT is able to measure the resulting reduction in collagen birefringence using depth resolved changes in the polarization of light propagated and reflected from the sample. In a previous study, we used a free space PS-OCT system at 850 nm to image in vivo the skin of rats burned for various amounts of time. Using a high-speed system at 1.3 micrometers has the advantages of greater depth penetration and reduction of motion artifacts due to breathing and small movements of the animal. Stokes vectors were calculated for each point in the scans and the relative birefringence was determined using different incident polarization states. Birefringence was correlated with actual burn depth determined by histological analysis. Our results show a marked difference between normal tissue and even the slightest burn, and a consistent trend for various degrees of burns.
UR - https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85135937635&origin=inward
M3 - Conference contribution
T3 - Optics InfoBase Conference Papers
SP - 268
EP - 274
BT - Biomedical Topical Meeting, BIOMED 2002
PB - Optica Publishing Group (formerly OSA)
T2 - Biomedical Topical Meeting, BIOMED 2002
Y2 - 7 April 2002 through 10 April 2002
ER -