@inbook{48e72b2053cf4eccae0db1f0ecf759dc,
title = "Cancer and meiotic gene expression: Two sides of the same coin?",
abstract = "Meiosis increases genetic diversity in offspring by generating genetically unique haploid gametes with reshuffled chromosomes. This process requires a specialized set of meiotic proteins, which facilitate chromosome recombination and segregation. However, re-expression of meiotic proteins in mitosis can have catastrophic oncogenic consequences and aberrant expression of meiotic proteins is a common occurrence in human tumors. Mechanistically, re-activation of meiotic genes in cancer promotes oncogenesis likely because cancers—conversely to healthy mitosis—are fueled by genetic instability which promotes tumor evolution, and evasion of immune response and treatment pressure. In this review, we explore similarities between meiotic and cancer cells with a particular focus on the oncogenic activation of meiotic genes in cancer. We emphasize the role of histones and their modifications, DNA methylation, genome organization, R-loops and the availability of distal enhancers.",
keywords = "Cancer, Cancer testis antigen, Chromatin, Germ cell cancer gene, Meiosis, R-loop, Synaptonemal complex, TAD, Topologically associated domain, Transcription",
author = "Sou, {Ieng Fong} and Geert Hamer and Wee-Wei Tee and Gerben Vader and McClurg, {Urszula Lucja}",
note = "Funding Information: The results presented in Fig. 2 are in whole based upon data generated by the TCGA Research Network: https://www.cancer.gov/tcga . U.L.M. was supported by University of Liverpool Tenure Track programme, the Royal Society Research Grant RG170342, North West Cancer Research RDG2021.15 and by the Wellcome Trustf 204822/Z/16/Z. I.F.S. was supported by a joint University of Liverpool—A* PhD programme. G.V. is financially supported by an Amsterdam UMC Research Fellowship. Publisher Copyright: {\textcopyright} 2022 Elsevier Inc.",
year = "2023",
month = jan,
doi = "https://doi.org/10.1016/bs.ctdb.2022.06.002",
language = "English",
isbn = "9780128201565",
series = "Current Topics in Developmental Biology",
publisher = "Academic Press Inc.",
pages = "43--68",
editor = "Francesca Cole",
booktitle = "Current Topics in Developmental Biology",
address = "United States",
}