Abstract
Cancer stem cells (CSCs) have been proposed as the driving force of tumorigenesis and the seeds of metastases. However, their existence and role remain a topic of intense debate. Recently, the identification of CSCs in endogenously developing mouse tumours has provided further support for this concept. Here I discuss the challenges in identifying CSCs, their dependency on a supportive niche and their role in metastasis, and propose that stemness is a flexible — rather than fixed — quality of tumour cells that can be lost and gained
| Original language | English |
|---|---|
| Pages (from-to) | 338-344 |
| Journal | Nature cell biology |
| Volume | 15 |
| Issue number | 4 |
| DOIs | |
| Publication status | Published - 2013 |