Cannabinoids modulate the P-type high-voltage-activated calcium currents in Purkinje neurons

A. Fisyunov; V. Tsintsadze; R. Min; N. Burnashev; N. Lozovaya

doi:https://doi.org/10.1152/jn.01227.2005

Cannabinoids modulate the P-type high-voltage-activated calcium currents in Purkinje neurons

A. Fisyunov, V. Tsintsadze, R. Min, N. Burnashev, N. Lozovaya

Research output: Contribution to journal › Article › Academic › peer-review

37 Citations (Scopus)

Abstract

Endocannabinoids released by postsynaptic cells inhibit neurotransmitter release in many central synapses by activating presynaptic cannabinoid CB1 receptors. In particular, in the cerebellum, endocannabinoids inhibit synaptic transmission at granule cell to Purkinje cell synapses by modulating presynaptic calcium influx via N-, P/Q-, and R-type calcium channels. Using whole cell patch-clamp techniques, we show that in addition to this presynaptic action, both synthetic and endogenous cannabinoids inhibit P-type calcium currents in isolated rat Purkinje neurons independent of CB1 receptor activation. The IC

Original language	English
Pages (from-to)	1267-1277
Number of pages	11
Journal	Journal of Neurophysiology
Volume	96
Issue number	3
DOIs	https://doi.org/10.1152/jn.01227.2005
Publication status	Published - Sept 2006

Keywords

Animals
Arachidonic Acids/pharmacology
Calcium Channel Blockers/pharmacology
Calcium Channels, P-Type/drug effects
Calcium Channels, R-Type/drug effects
Cannabinoids/pharmacology
Cerebellum/physiology
Endocannabinoids
In Vitro Techniques
Kinetics
Patch-Clamp Techniques
Polyunsaturated Alkamides
Purkinje Cells/drug effects
Rats
Rats, Sprague-Dawley
Rats, Wistar
TRPV Cation Channels/drug effects

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

https://doi.org/10.1152/jn.01227.2005

Cite this

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title = "Cannabinoids modulate the P-type high-voltage-activated calcium currents in Purkinje neurons",

abstract = "Endocannabinoids released by postsynaptic cells inhibit neurotransmitter release in many central synapses by activating presynaptic cannabinoid CB1 receptors. In particular, in the cerebellum, endocannabinoids inhibit synaptic transmission at granule cell to Purkinje cell synapses by modulating presynaptic calcium influx via N-, P/Q-, and R-type calcium channels. Using whole cell patch-clamp techniques, we show that in addition to this presynaptic action, both synthetic and endogenous cannabinoids inhibit P-type calcium currents in isolated rat Purkinje neurons independent of CB1 receptor activation. The IC",

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author = "A. Fisyunov and V. Tsintsadze and R. Min and N. Burnashev and N. Lozovaya",

year = "2006",

month = sep,

doi = "https://doi.org/10.1152/jn.01227.2005",

language = "English",

volume = "96",

pages = "1267--1277",

journal = "Journal of Neurophysiology",

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publisher = "American Physiological Society",

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TY - JOUR

T1 - Cannabinoids modulate the P-type high-voltage-activated calcium currents in Purkinje neurons

AU - Fisyunov, A.

AU - Tsintsadze, V.

AU - Min, R.

AU - Burnashev, N.

AU - Lozovaya, N.

PY - 2006/9

Y1 - 2006/9

N2 - Endocannabinoids released by postsynaptic cells inhibit neurotransmitter release in many central synapses by activating presynaptic cannabinoid CB1 receptors. In particular, in the cerebellum, endocannabinoids inhibit synaptic transmission at granule cell to Purkinje cell synapses by modulating presynaptic calcium influx via N-, P/Q-, and R-type calcium channels. Using whole cell patch-clamp techniques, we show that in addition to this presynaptic action, both synthetic and endogenous cannabinoids inhibit P-type calcium currents in isolated rat Purkinje neurons independent of CB1 receptor activation. The IC

AB - Endocannabinoids released by postsynaptic cells inhibit neurotransmitter release in many central synapses by activating presynaptic cannabinoid CB1 receptors. In particular, in the cerebellum, endocannabinoids inhibit synaptic transmission at granule cell to Purkinje cell synapses by modulating presynaptic calcium influx via N-, P/Q-, and R-type calcium channels. Using whole cell patch-clamp techniques, we show that in addition to this presynaptic action, both synthetic and endogenous cannabinoids inhibit P-type calcium currents in isolated rat Purkinje neurons independent of CB1 receptor activation. The IC

KW - Animals

KW - Arachidonic Acids/pharmacology

KW - Calcium Channel Blockers/pharmacology

KW - Calcium Channels, P-Type/drug effects

KW - Calcium Channels, R-Type/drug effects

KW - Cannabinoids/pharmacology

KW - Cerebellum/physiology

KW - Endocannabinoids

KW - In Vitro Techniques

KW - Kinetics

KW - Patch-Clamp Techniques

KW - Polyunsaturated Alkamides

KW - Purkinje Cells/drug effects

KW - Rats

KW - Rats, Sprague-Dawley

KW - Rats, Wistar

KW - TRPV Cation Channels/drug effects

U2 - https://doi.org/10.1152/jn.01227.2005

DO - https://doi.org/10.1152/jn.01227.2005

M3 - Article

C2 - 16738209

SN - 0022-3077

VL - 96

SP - 1267

EP - 1277

JO - Journal of Neurophysiology

JF - Journal of Neurophysiology

IS - 3

ER -