Cannabinoids modulate the P-type high-voltage-activated calcium currents in Purkinje neurons

A. Fisyunov, V. Tsintsadze, R. Min, N. Burnashev, N. Lozovaya

Research output: Contribution to journalArticleAcademicpeer-review

37 Citations (Scopus)


Endocannabinoids released by postsynaptic cells inhibit neurotransmitter release in many central synapses by activating presynaptic cannabinoid CB1 receptors. In particular, in the cerebellum, endocannabinoids inhibit synaptic transmission at granule cell to Purkinje cell synapses by modulating presynaptic calcium influx via N-, P/Q-, and R-type calcium channels. Using whole cell patch-clamp techniques, we show that in addition to this presynaptic action, both synthetic and endogenous cannabinoids inhibit P-type calcium currents in isolated rat Purkinje neurons independent of CB1 receptor activation. The IC
Original languageEnglish
Pages (from-to)1267-1277
Number of pages11
JournalJournal of Neurophysiology
Issue number3
Publication statusPublished - Sept 2006


  • Animals
  • Arachidonic Acids/pharmacology
  • Calcium Channel Blockers/pharmacology
  • Calcium Channels, P-Type/drug effects
  • Calcium Channels, R-Type/drug effects
  • Cannabinoids/pharmacology
  • Cerebellum/physiology
  • Endocannabinoids
  • In Vitro Techniques
  • Kinetics
  • Patch-Clamp Techniques
  • Polyunsaturated Alkamides
  • Purkinje Cells/drug effects
  • Rats
  • Rats, Sprague-Dawley
  • Rats, Wistar
  • TRPV Cation Channels/drug effects

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