Cardiac ion channel dysfunction underlying sudden cardiac arrest associated with noncardiac drugs

Sudden cardiac arrest (SCA) is a worldwide public health problem and is the main cause of death from cardiovascular disease. Drugs, including noncardiac drugs (drugs to treat noncardiac conditions), may impact on the risk of the occurrence of SCA. This may be due to the ability of these drugs to modify the cardiac ion channels whose concerted activity underlies the cardiac action