TY - JOUR
T1 - Cardiac resynchronization induces favorable neurohumoral changes
AU - Erol-Yilmaz, Ayten
AU - Verberne, Hein J.
AU - Schrama, Tim A.
AU - Hrudova, Jana
AU - de Winter, Robbert J.
AU - van Eck-Smit, Berthe L. F.
AU - Bax, Jeroen J.
AU - Schalij, Martin J.
AU - Wilde, Arthur A.
AU - Tukkie, Raymond
PY - 2005
Y1 - 2005
N2 - Aim: The aim of this article is to examine whether cardiac resynchronization therapy (CRT) induces improvements in the neurohumoral system. Methods and Results: Thirteen patients with HF (left ventricular (LV) ejection fraction <35%) were included. Before and after 6 months of CRT, myocardial I-123-metaiodobenzylguanidine (I-123-MIBG) uptake indices, used as an index of neural norepinephrine reuptake and retention, and brain natriuretic peptide (BNP) levels, used as an index of LV end-diastolic pressure, NYHA classification and echocardiographic indices were assessed. Six months of CRT resulted in significant improvement in (1) NYHA classification and reduction in QRS width (P <0.001), (2) decrease of LV end-diastolic diameter (P = 0.005), LV end-systolic diameter (P = 0.005), septal to lateral delay (P = 0.01) and mitral regurgitation (MR, P = 0.04), (3) delayed I-123-MIBG heart/mediastinum ratios improved (P = 0.03) and I-123-MIBG washout decreased (P = 0.001), and (4) BNP levels decreased (P = 0.001). Conclusions: Parallel to significant functional improvement and echocardiographic reverse remodeling and resynchronization, our data indicate that CRT induces favorable changes in the neurohumoral system
AB - Aim: The aim of this article is to examine whether cardiac resynchronization therapy (CRT) induces improvements in the neurohumoral system. Methods and Results: Thirteen patients with HF (left ventricular (LV) ejection fraction <35%) were included. Before and after 6 months of CRT, myocardial I-123-metaiodobenzylguanidine (I-123-MIBG) uptake indices, used as an index of neural norepinephrine reuptake and retention, and brain natriuretic peptide (BNP) levels, used as an index of LV end-diastolic pressure, NYHA classification and echocardiographic indices were assessed. Six months of CRT resulted in significant improvement in (1) NYHA classification and reduction in QRS width (P <0.001), (2) decrease of LV end-diastolic diameter (P = 0.005), LV end-systolic diameter (P = 0.005), septal to lateral delay (P = 0.01) and mitral regurgitation (MR, P = 0.04), (3) delayed I-123-MIBG heart/mediastinum ratios improved (P = 0.03) and I-123-MIBG washout decreased (P = 0.001), and (4) BNP levels decreased (P = 0.001). Conclusions: Parallel to significant functional improvement and echocardiographic reverse remodeling and resynchronization, our data indicate that CRT induces favorable changes in the neurohumoral system
U2 - https://doi.org/10.1111/j.1540-8159.2005.09508.x
DO - https://doi.org/10.1111/j.1540-8159.2005.09508.x
M3 - Article
C2 - 15826264
SN - 0147-8389
VL - 28
SP - 304
EP - 310
JO - Pacing and clinical electrophysiology
JF - Pacing and clinical electrophysiology
IS - 4
ER -