TY - JOUR
T1 - Cardiomyocyte progenitor cell-derived exosomes stimulate migration of endothelial cells
AU - Vrijsen, K. R.
AU - Sluijter, J. P. G.
AU - Schuchardt, M. W. L.
AU - van Balkom, B. W. M.
AU - Noort, W. A.
AU - Chamuleau, S. A. J.
AU - Doevendans, P. A. F. M.
PY - 2010
Y1 - 2010
N2 - Patients suffering from heart failure as a result of myocardial infarction are in need of heart transplantation. Unfortunately the number of donor hearts is very low and therefore new therapies are subject of investigation. Cell transplantation therapy upon myocardial infarction is a very promising strategy to replace the dead myocardium with viable cardiomyocytes, smooth muscle cells and endothelial cells, thereby reducing scarring and improving cardiac performance. Despite promising results, resulting in reduced infarct size and improved cardiac function on short term, only a few cells survive the ischemic milieu and are retained in the heart, thereby minimizing long-term effects. Although new capillaries and cardiomyocytes are formed around the infarcted area, only a small percentage of the transplanted cells can be detected months after myocardial infarction. This suggests the stimulation of an endogenous regenerative capacity of the heart upon cell transplantation, resulting from release of growth factor, cytokine and other paracrine molecules by the progenitor cells - the so-called paracrine hypothesis. Here, we focus on a relative new component of paracrine signalling, i.e. exosomes. We are interested in the release and function of exosomes derived from cardiac progenitor cells and studied their effects on the migratory capacity of endothelial cells. © 2010 The Authors Journal compilation © 2010 Foundation for Cellular and Molecular Medicine/Blackwell Publishing Ltd.
AB - Patients suffering from heart failure as a result of myocardial infarction are in need of heart transplantation. Unfortunately the number of donor hearts is very low and therefore new therapies are subject of investigation. Cell transplantation therapy upon myocardial infarction is a very promising strategy to replace the dead myocardium with viable cardiomyocytes, smooth muscle cells and endothelial cells, thereby reducing scarring and improving cardiac performance. Despite promising results, resulting in reduced infarct size and improved cardiac function on short term, only a few cells survive the ischemic milieu and are retained in the heart, thereby minimizing long-term effects. Although new capillaries and cardiomyocytes are formed around the infarcted area, only a small percentage of the transplanted cells can be detected months after myocardial infarction. This suggests the stimulation of an endogenous regenerative capacity of the heart upon cell transplantation, resulting from release of growth factor, cytokine and other paracrine molecules by the progenitor cells - the so-called paracrine hypothesis. Here, we focus on a relative new component of paracrine signalling, i.e. exosomes. We are interested in the release and function of exosomes derived from cardiac progenitor cells and studied their effects on the migratory capacity of endothelial cells. © 2010 The Authors Journal compilation © 2010 Foundation for Cellular and Molecular Medicine/Blackwell Publishing Ltd.
UR - https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=77954724494&origin=inward
UR - https://www.ncbi.nlm.nih.gov/pubmed/20465578
U2 - https://doi.org/10.1111/j.1582-4934.2010.01081.x
DO - https://doi.org/10.1111/j.1582-4934.2010.01081.x
M3 - Review article
C2 - 20465578
SN - 1582-1838
VL - 14
SP - 1064
EP - 1070
JO - Journal of cellular and molecular medicine
JF - Journal of cellular and molecular medicine
IS - 5
ER -