TY - JOUR
T1 - Cardiotoxicity of cytotoxic drugs
AU - Schimmel, Kirsten J. M.
AU - Richel, Dick J.
AU - van den Brink, Renée B. A.
AU - Guchelaar, Henk-Jan
PY - 2004
Y1 - 2004
N2 - Cardiotoxicity is a well-known side effect of several cytotoxic drugs, especially of the anthracyclines and can lead to long term morbidity. The mechanism of anthracycline induced cardiotoxicity seems to involve the formation of free radicals Leading to oxidative stress. This may cause apoptosis of cardiac cells or immunologic reactions. However, alternative mechanisms may play a role in anthracycline induced cardiotoxicity. Cardiac protection can be achieved by limitation of the cumulative dose. Furthermore, addition of the antioxidant and iron chelator dexrazoxane to anthracycline therapy has shown to be effective in lowering the incidence of anthracycline induced cardiotoxicity. Other cytotoxic drugs such as 5-fluorouracit, cyclophosphamide and the taxoids are associated with cardiotoxicity as well, although little is known about the possible mechanisms. Recently, it appeared that some novel cytotoxic drugs such as trastuzumab and cyclopentenyl cytosine also show cardiotoxic side effects. (C) 2003 Elsevier Ltd. All rights reserved
AB - Cardiotoxicity is a well-known side effect of several cytotoxic drugs, especially of the anthracyclines and can lead to long term morbidity. The mechanism of anthracycline induced cardiotoxicity seems to involve the formation of free radicals Leading to oxidative stress. This may cause apoptosis of cardiac cells or immunologic reactions. However, alternative mechanisms may play a role in anthracycline induced cardiotoxicity. Cardiac protection can be achieved by limitation of the cumulative dose. Furthermore, addition of the antioxidant and iron chelator dexrazoxane to anthracycline therapy has shown to be effective in lowering the incidence of anthracycline induced cardiotoxicity. Other cytotoxic drugs such as 5-fluorouracit, cyclophosphamide and the taxoids are associated with cardiotoxicity as well, although little is known about the possible mechanisms. Recently, it appeared that some novel cytotoxic drugs such as trastuzumab and cyclopentenyl cytosine also show cardiotoxic side effects. (C) 2003 Elsevier Ltd. All rights reserved
U2 - https://doi.org/10.1016/j.ctrv.2003.07.003
DO - https://doi.org/10.1016/j.ctrv.2003.07.003
M3 - Review article
C2 - 15023436
SN - 0305-7372
VL - 30
SP - 181
EP - 191
JO - Cancer Treatment Reviews
JF - Cancer Treatment Reviews
IS - 2
ER -