Cardiovascular disease in inflammatory rheumatic diseases

Santos Castañeda, Michael T Nurmohamed, Miguel A González-Gay

Research output: Contribution to journalReview articleAcademicpeer-review

91 Citations (Scopus)


Chronic inflammatory rheumatic diseases (IRD), including rheumatoid arthritis, ankylosing spondylitis, and psoriatic arthritis, are prevalent conditions worldwide, with a considerable burden on healthcare systems. They are associated with increased cardiovascular (CV) morbidity and mortality. In this review, we focused on the epidemiology, traditional CV risk factors, genetics, and the link between chronic inflammation, atherosclerosis, and CV disease. Remarkably, patients with IRD have higher vulnerability to atheromatous plaques. The risk of unstable plaques is higher in patients with rheumatoid arthritis than in controls. Active disease is a characteristic ascribed to vulnerability and rupture of plaques and a cause of thrombosis in IRD. Management of CV risk in patients with IRD includes optimal control of disease activity. CV risk stratification by applying risk charts is also essential. Imaging techniques might be useful to determine the actual CV risk of patients with IRD who are included in the category of intermediate or moderate CV risk.

Original languageEnglish
Pages (from-to)851-869
Number of pages19
JournalBaillière's Best Practice and Research. Clinical Rheumatology
Issue number5
Publication statusPublished - 2016

Cite this