TY - JOUR
T1 - Cardiovascular medication use and cardiovascular disease in children and adolescents with type 1 diabetes: a population-based cohort study
AU - Ahmadizar, Fariba
AU - Fazeli Farsani, Soulmaz
AU - Souverein, Patrick C.
AU - van der Vorst, Marja Mj
AU - de Boer, Anthonius
AU - Maitland-van der Zee, Anke H.
PY - 2016
Y1 - 2016
N2 - ObjectivesTo investigate the 5-yr prevalence and incidence rates of cardiovascular medication and cardiovascular disease before and after onset of type 1 diabetes (T1D) in children and adolescents. MethodsChildren and adolescents ( <19yr) with T1D (n=925), defined as those who received at least two insulin prescriptions, and a four times larger reference cohort (n=3591) with the same age and gender in the Dutch PHARMO Record Linkage System (RLS) were studied in a retrospective cohort study between 1999 and 2009. The date of first insulin dispensing was selected as the index date. ResultsThe overall prevalence rate of cardiovascular medication use was substantially higher in the T1D cohort before (2.2 vs. 1.0%, p <0.001) and after (9.2 vs. 3.2%, p <0.001) the index date. After the index date angiotensin-converting enzyme inhibitors (2.0%) and statins (1.5%) were the most prevalent cardiovascular medications in the T1D cohort. The highest incidence rate of cardiovascular medication use was observed in the first year after the index date [28.1 per 1000 person years (PY)]. Furthermore, three type 1 diabetic patients were hospitalized due to cardiomyopathy (n=2) and heart failure (n=1) and one child from the reference group was hospitalized due to cardiomyopathy in the 5yr after the index date. ConclusionsChildren with T1D were more likely to use cardiovascular medications in the years before and after the onset of diabetes. Our study emphasizes the importance of routine screening tests and timely treatment of CVD risk factors in the pediatric population with diabetes
AB - ObjectivesTo investigate the 5-yr prevalence and incidence rates of cardiovascular medication and cardiovascular disease before and after onset of type 1 diabetes (T1D) in children and adolescents. MethodsChildren and adolescents ( <19yr) with T1D (n=925), defined as those who received at least two insulin prescriptions, and a four times larger reference cohort (n=3591) with the same age and gender in the Dutch PHARMO Record Linkage System (RLS) were studied in a retrospective cohort study between 1999 and 2009. The date of first insulin dispensing was selected as the index date. ResultsThe overall prevalence rate of cardiovascular medication use was substantially higher in the T1D cohort before (2.2 vs. 1.0%, p <0.001) and after (9.2 vs. 3.2%, p <0.001) the index date. After the index date angiotensin-converting enzyme inhibitors (2.0%) and statins (1.5%) were the most prevalent cardiovascular medications in the T1D cohort. The highest incidence rate of cardiovascular medication use was observed in the first year after the index date [28.1 per 1000 person years (PY)]. Furthermore, three type 1 diabetic patients were hospitalized due to cardiomyopathy (n=2) and heart failure (n=1) and one child from the reference group was hospitalized due to cardiomyopathy in the 5yr after the index date. ConclusionsChildren with T1D were more likely to use cardiovascular medications in the years before and after the onset of diabetes. Our study emphasizes the importance of routine screening tests and timely treatment of CVD risk factors in the pediatric population with diabetes
U2 - https://doi.org/10.1111/pedi.12302
DO - https://doi.org/10.1111/pedi.12302
M3 - Article
C2 - 26260711
SN - 1399-543X
VL - 17
SP - 433
EP - 440
JO - Pediatric diabetes
JF - Pediatric diabetes
IS - 6
ER -