TY - JOUR
T1 - Cardiovascular Molecular Imaging With Fluorine-19 MRI
T2 - The Road to the Clinic
AU - van Heeswijk, Ruud B.
AU - Bauer, Wolfgang R.
AU - Bönner, Florian
AU - Janjic, Jelena M.
AU - Mulder, Willem J. M.
AU - Schreiber, Laura M.
AU - Schwitter, Juerg
AU - Flögel, Ulrich
PY - 2023/9/1
Y1 - 2023/9/1
N2 - Fluorine-19 (19F) magnetic resonance imaging is a unique quantitative molecular imaging modality that makes use of an injectable fluorine-containing tracer that generates the only visible 19F signal in the body. This hot spot imaging technique has recently been used to characterize a wide array of cardiovascular diseases and seen a broad range of technical improvements. Concurrently, its potential to be translated to the clinical setting is being explored. This review provides an overview of this emerging field and demonstrates its diagnostic potential, which shows promise for clinical translation. We will describe 19F magnetic resonance imaging hardware, pulse sequences, and tracers, followed by an overview of cardiovascular applications. Finally, the challenges on the road to clinical translation are discussed.
AB - Fluorine-19 (19F) magnetic resonance imaging is a unique quantitative molecular imaging modality that makes use of an injectable fluorine-containing tracer that generates the only visible 19F signal in the body. This hot spot imaging technique has recently been used to characterize a wide array of cardiovascular diseases and seen a broad range of technical improvements. Concurrently, its potential to be translated to the clinical setting is being explored. This review provides an overview of this emerging field and demonstrates its diagnostic potential, which shows promise for clinical translation. We will describe 19F magnetic resonance imaging hardware, pulse sequences, and tracers, followed by an overview of cardiovascular applications. Finally, the challenges on the road to clinical translation are discussed.
KW - cardiovascular disease
KW - cell tracking
KW - fluorine-19
KW - inflammation
KW - magnetic resonance imaging
KW - thrombosis
KW - translational research, biomedical
UR - http://www.scopus.com/inward/record.url?scp=85171900950&partnerID=8YFLogxK
U2 - https://doi.org/10.1161/CIRCIMAGING.123.014742
DO - https://doi.org/10.1161/CIRCIMAGING.123.014742
M3 - Review article
C2 - 37725674
SN - 1941-9651
VL - 16
SP - e014742
JO - Circulation. Cardiovascular imaging
JF - Circulation. Cardiovascular imaging
IS - 9
ER -