TY - JOUR
T1 - Cardiovascular Risk Scores among Asymptomatic Adults with Haemophilia
AU - Camelo, Ricardo Mesquita
AU - Caram-Deelder, Camila
AU - Duarte, Bruna Pontes
AU - Moura, Marilia Carolina Braga de
AU - Costa, Neuza Cavalcanti de Moraes
AU - Costa, Iris Maciel
AU - Vanderlei, Ana Maria
AU - Guimarães, Tania Maria Rocha
AU - Gouw, Samantha
AU - Rezende, Suely Meireles
AU - Bom, Johanna van der
N1 - Funding Information: Camelo RM received scholarship (PDSE- 88881.362041/2019-1) from the CAPES Foundation, an agency under the Ministry of Education of Brazil, in order to conduct part of his doctoral research as a visiting student at Leiden University Medical Centre in the Netherlands. Publisher Copyright: © 2023, Sociedade Brasileira de Cardiologia. All rights reserved.
PY - 2023
Y1 - 2023
N2 - Background: The mortality rate of Brazilian people with haemophilia (PwH) is decreasing, but the relative incidence of deaths associated with cardiovascular disease (CVD) is increasing. Objectives: We aimed to describe the CVD risk score of PwH according to Pooled Cohort Equations Risk (PCER) Calculator tool and its treatment recommendations. We also compared the PCER estimates with the respective Framingham Risk Score (FRS). Methods: This cross-sectional study included male PwH ≥ 40 years treated at the Comprehensive Haemophilia Treatment Centre of Pernambuco (Recife/Brazil). PwH with a previous CVD event or a low-density lipid cholesterol ≥ 5.0 mmol/L were excluded. Interviews, medical file reviews, and blood tests were performed. The PCER tool was used to estimate the CVD risk and compare it with the respective FRS. A p-value < 0.05 was accepted as statistically significant. Results: Thirty PwH were included. Median age was 51.5 [interquartile range-IQR; 46.0-59.5] years. The prevalence of obesity, systemic arterial hypertension, diabetes mellitus, hypertriglyceridaemia, hypercholesterolaemia, and hypoHDLaemia were 20%, 67%, 24%, 14%, 47%, and 23%, respectively. The median PCER score was 6.9% [IQR; 3.1-13.2], with 50% having a high risk (PCER ≥ 7.5%). Statin use was suggested for 54% of PwH. Blood pressure was poorly controlled in 47% of PwH. The agreement between PCER and FRS was 80% (κ = 0.60; p = 0.001). Conclusions: Half of the male people with haemophilia aged 40 years or older had a 10-year high risk of developing CVD with strong recommendations to improve control of dyslipidaemia and blood pressure.
AB - Background: The mortality rate of Brazilian people with haemophilia (PwH) is decreasing, but the relative incidence of deaths associated with cardiovascular disease (CVD) is increasing. Objectives: We aimed to describe the CVD risk score of PwH according to Pooled Cohort Equations Risk (PCER) Calculator tool and its treatment recommendations. We also compared the PCER estimates with the respective Framingham Risk Score (FRS). Methods: This cross-sectional study included male PwH ≥ 40 years treated at the Comprehensive Haemophilia Treatment Centre of Pernambuco (Recife/Brazil). PwH with a previous CVD event or a low-density lipid cholesterol ≥ 5.0 mmol/L were excluded. Interviews, medical file reviews, and blood tests were performed. The PCER tool was used to estimate the CVD risk and compare it with the respective FRS. A p-value < 0.05 was accepted as statistically significant. Results: Thirty PwH were included. Median age was 51.5 [interquartile range-IQR; 46.0-59.5] years. The prevalence of obesity, systemic arterial hypertension, diabetes mellitus, hypertriglyceridaemia, hypercholesterolaemia, and hypoHDLaemia were 20%, 67%, 24%, 14%, 47%, and 23%, respectively. The median PCER score was 6.9% [IQR; 3.1-13.2], with 50% having a high risk (PCER ≥ 7.5%). Statin use was suggested for 54% of PwH. Blood pressure was poorly controlled in 47% of PwH. The agreement between PCER and FRS was 80% (κ = 0.60; p = 0.001). Conclusions: Half of the male people with haemophilia aged 40 years or older had a 10-year high risk of developing CVD with strong recommendations to improve control of dyslipidaemia and blood pressure.
KW - Heart Disease Risk Factors
KW - Hemophilia A
KW - Hemophilia B
KW - Primary Prevention
UR - http://www.scopus.com/inward/record.url?scp=85171808343&partnerID=8YFLogxK
U2 - https://doi.org/10.36660/abc.20230004
DO - https://doi.org/10.36660/abc.20230004
M3 - Article
C2 - 37729292
SN - 0066-782X
VL - 120
SP - e20230004
JO - Arquivos Brasileiros de Cardiologia
JF - Arquivos Brasileiros de Cardiologia
IS - 9
M1 - e20230004
ER -