Care after premenopausal risk-reducing salpingo-oophorectomy in high-risk women: Scoping review and international consensus recommendations

Denise R Nebgen, Susan M Domchek, Joanne Kotsopoulos, Joanne A de Hullu, Emma J Crosbie, Vincent Singh Paramanandam, Monique Brood van Zanten, Barbara M Norquist, Theresa Guise, Serge Rozenberg, Allison W Kurian, Holly J Pederson, Nese Yuksel, Rachel Michaelson-Cohen, Sharon L Bober, Agnaldo Lopes da Silva Filho, Nora Johansen, F Guidozzi, D Gareth Evans, Usha MenonSheryl A Kingsberg, C Bethan Powell, Giovanni Grandi, Claudia Marchetti, Michelle Jacobson, Donal J Brennan, Martha Hickey

Research output: Contribution to journalReview articleAcademicpeer-review

5 Citations (Scopus)


Women at high inherited risk of ovarian cancer are offered risk-reducing salpingo-oophorectomy (RRSO) from age 35 to 45 years. Although potentially life-saving, RRSO may induce symptoms that negatively affect quality of life and impair long-term health. Clinical care following RRSO is often suboptimal. This scoping review describes how RRSO affects short- and long-term health and provides evidence-based international consensus recommendations for care from preoperative counselling to long-term disease prevention. This includes the efficacy and safety of hormonal and non-hormonal treatments for vasomotor symptoms, sleep disturbance and sexual dysfunction and effective approaches to prevent bone and cardiovascular disease.

Original languageEnglish
Pages (from-to)1437-1450
Number of pages14
JournalBJOG: An International Journal of Obstetrics & Gynaecology
Issue number12
Early online date2 May 2023
Publication statusPublished - Nov 2023


  • BRCA1
  • BRCA2
  • early menopause
  • hormone replacement therapy
  • hot flushes
  • ovarian cancer
  • risk-reducing salpingo-oophorectomy
  • sexual function
  • surgical menopause

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