Carotid artery intima-media thickness, but not coronary artery calcium, predicts vascular resistance in patients evaluated for coronary artery disease

I. Danad; P.G. Raijmakers; P. Kamali; H.J. Harms; S. de Haan; J.M. Lubberink; C. van Kuijk; O.S. Hoekstra; A.A. Lammertsma; Y.M. Smulders; M.W. Heijmans; I.I. Tulevski; A.C. van Rossum; P. Knaapen

doi:https://doi.org/10.1093/ehjci/jes038

Carotid artery intima-media thickness, but not coronary artery calcium, predicts vascular resistance in patients evaluated for coronary artery disease

I. Danad, P.G. Raijmakers, P. Kamali, H.J. Harms, S. de Haan, J.M. Lubberink, C. van Kuijk, O.S. Hoekstra, A.A. Lammertsma, Y.M. Smulders, M.W. Heijmans, I.I. Tulevski, A.C. van Rossum, P. Knaapen

Research output: Contribution to journal › Article › Academic › peer-review

12 Citations (Scopus)

Abstract

Aims: There is growing evidence that coronary artery disease (CAD) affects not only the conduit epicardial coronary arteries, but also the microvascular coronary bed. Moreover, coronary microvascular dysfunction (CMVD) often precedes the stage of clinically overt epicardial CAD. Coronary artery calcium (CAC) and carotid intima-media thickness (C-IMT) measured with computed tomography (CT) and ultrasound, respectively, are among the available techniques to non-invasively assess atherosclerotic burden. An increased CAC score and C-IMT have also been associated with CMVD. It is therefore of interest to explore and compare the potential of CAC against C-IMT to predict minimal coronary vascular resistance (CVR). Methods and results: We evaluated 120 patients (mean age 56 ± 9 years, 58 men) without a documented history of CAD in whom obstructive CAD was excluded. All patients underwent C-IMT measurements, CAC scoring, and vasodilator stress

Original language	English
Pages (from-to)	317-323
Journal	European Heart Journal-Cardiovascular Imaging
Volume	13
Issue number	4
DOIs	https://doi.org/10.1093/ehjci/jes038
Publication status	Published - 2012

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Cite this

Danad, I., Raijmakers, P. G., Kamali, P., Harms, H. J., de Haan, S., Lubberink, J. M., van Kuijk, C., Hoekstra, O. S., Lammertsma, A. A., Smulders, Y. M., Heijmans, M. W., Tulevski, I. I., van Rossum, A. C., & Knaapen, P. (2012). Carotid artery intima-media thickness, but not coronary artery calcium, predicts vascular resistance in patients evaluated for coronary artery disease. European Heart Journal-Cardiovascular Imaging, 13(4), 317-323. https://doi.org/10.1093/ehjci/jes038

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title = "Carotid artery intima-media thickness, but not coronary artery calcium, predicts vascular resistance in patients evaluated for coronary artery disease",

abstract = "Aims: There is growing evidence that coronary artery disease (CAD) affects not only the conduit epicardial coronary arteries, but also the microvascular coronary bed. Moreover, coronary microvascular dysfunction (CMVD) often precedes the stage of clinically overt epicardial CAD. Coronary artery calcium (CAC) and carotid intima-media thickness (C-IMT) measured with computed tomography (CT) and ultrasound, respectively, are among the available techniques to non-invasively assess atherosclerotic burden. An increased CAC score and C-IMT have also been associated with CMVD. It is therefore of interest to explore and compare the potential of CAC against C-IMT to predict minimal coronary vascular resistance (CVR). Methods and results: We evaluated 120 patients (mean age 56 ± 9 years, 58 men) without a documented history of CAD in whom obstructive CAD was excluded. All patients underwent C-IMT measurements, CAC scoring, and vasodilator stress",

author = "I. Danad and P.G. Raijmakers and P. Kamali and H.J. Harms and {de Haan}, S. and J.M. Lubberink and {van Kuijk}, C. and O.S. Hoekstra and A.A. Lammertsma and Y.M. Smulders and M.W. Heijmans and I.I. Tulevski and {van Rossum}, A.C. and P. Knaapen",

year = "2012",

doi = "https://doi.org/10.1093/ehjci/jes038",

language = "English",

volume = "13",

pages = "317--323",

journal = "European Heart Journal-Cardiovascular Imaging",

issn = "2047-2404",

publisher = "Oxford University Press",

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}

Danad, I , Raijmakers, PG, Kamali, P, Harms, HJ, de Haan, S, Lubberink, JM, van Kuijk, C, Hoekstra, OS, Lammertsma, AA , Smulders, YM , Heijmans, MW, Tulevski, II, van Rossum, AC & Knaapen, P 2012, 'Carotid artery intima-media thickness, but not coronary artery calcium, predicts vascular resistance in patients evaluated for coronary artery disease', European Heart Journal-Cardiovascular Imaging, vol. 13, no. 4, pp. 317-323. https://doi.org/10.1093/ehjci/jes038

TY - JOUR

T1 - Carotid artery intima-media thickness, but not coronary artery calcium, predicts vascular resistance in patients evaluated for coronary artery disease

AU - Danad, I.

AU - Raijmakers, P.G.

AU - Kamali, P.

AU - Harms, H.J.

AU - de Haan, S.

AU - Lubberink, J.M.

AU - van Kuijk, C.

AU - Hoekstra, O.S.

AU - Lammertsma, A.A.

AU - Smulders, Y.M.

AU - Heijmans, M.W.

AU - Tulevski, I.I.

AU - van Rossum, A.C.

AU - Knaapen, P.

PY - 2012

Y1 - 2012

N2 - Aims: There is growing evidence that coronary artery disease (CAD) affects not only the conduit epicardial coronary arteries, but also the microvascular coronary bed. Moreover, coronary microvascular dysfunction (CMVD) often precedes the stage of clinically overt epicardial CAD. Coronary artery calcium (CAC) and carotid intima-media thickness (C-IMT) measured with computed tomography (CT) and ultrasound, respectively, are among the available techniques to non-invasively assess atherosclerotic burden. An increased CAC score and C-IMT have also been associated with CMVD. It is therefore of interest to explore and compare the potential of CAC against C-IMT to predict minimal coronary vascular resistance (CVR). Methods and results: We evaluated 120 patients (mean age 56 ± 9 years, 58 men) without a documented history of CAD in whom obstructive CAD was excluded. All patients underwent C-IMT measurements, CAC scoring, and vasodilator stress

AB - Aims: There is growing evidence that coronary artery disease (CAD) affects not only the conduit epicardial coronary arteries, but also the microvascular coronary bed. Moreover, coronary microvascular dysfunction (CMVD) often precedes the stage of clinically overt epicardial CAD. Coronary artery calcium (CAC) and carotid intima-media thickness (C-IMT) measured with computed tomography (CT) and ultrasound, respectively, are among the available techniques to non-invasively assess atherosclerotic burden. An increased CAC score and C-IMT have also been associated with CMVD. It is therefore of interest to explore and compare the potential of CAC against C-IMT to predict minimal coronary vascular resistance (CVR). Methods and results: We evaluated 120 patients (mean age 56 ± 9 years, 58 men) without a documented history of CAD in whom obstructive CAD was excluded. All patients underwent C-IMT measurements, CAC scoring, and vasodilator stress

U2 - https://doi.org/10.1093/ehjci/jes038

DO - https://doi.org/10.1093/ehjci/jes038

M3 - Article

SN - 2047-2404

VL - 13

SP - 317

EP - 323

JO - European Heart Journal-Cardiovascular Imaging

JF - European Heart Journal-Cardiovascular Imaging

IS - 4

ER -