Carotid intima media thickness in rheumatoid arthritis as compared to control subjects: a meta-analysis

A.M. van Sijl; M.J.L. Peters; D.L. Knol; H.C.W. de Vet; M.A. Gonzalez-Gay; Y.M. Smulders; B.A.C. Dijkmans; M.T. Nurmohamed

doi:https://doi.org/10.1016/j.semarthrit.2010.06.006

Carotid intima media thickness in rheumatoid arthritis as compared to control subjects: a meta-analysis

A.M. van Sijl, M.J.L. Peters, D.L. Knol, H.C.W. de Vet, M.A. Gonzalez-Gay, Y.M. Smulders, B.A.C. Dijkmans, M.T. Nurmohamed

Research output: Contribution to journal › Article › Academic › peer-review

126 Citations (Scopus)

Abstract

Objectives: Rheumatoid arthritis (RA) is associated with increased risk of cardiovascular disease. Carotid intima media thickness (cIMT) is frequently used to identify populations at elevated cardiovascular risk. A systematic literature search and meta-analysis were performed to evaluate cIMT difference between RA and controls. Methods: The literature was screened to identify all available studies comparing cIMT in RA patients and controls. Random effects meta-analysis was performed to estimate the overall mean cIMT difference between both groups. Meta-regression was performed to assess the influence of age and the degree of comparability regarding established cardiovascular risk factors on cIMT difference. Potential publication bias was examined by a funnel plot and Egger test. Results: From 22 studies, cIMT data were available from 1384 RA patients and 1147 controls. In 17 of the studies, RA patients had a statistically significantly greater cIMT. The overall mean cIMT difference was 0.09 mm (95%CI: 0.07-0.11 mm). Heterogeneity was observed (I

Original language	English
Pages (from-to)	389-397
Journal	Seminars in Arthritis and Rheumatism
Volume	40
Issue number	5
DOIs	https://doi.org/10.1016/j.semarthrit.2010.06.006
Publication status	Published - 2011

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https://doi.org/10.1016/j.semarthrit.2010.06.006

Cite this

@article{1323c4db8c0a4940a52b664f1165c740,

title = "Carotid intima media thickness in rheumatoid arthritis as compared to control subjects: a meta-analysis",

abstract = "Objectives: Rheumatoid arthritis (RA) is associated with increased risk of cardiovascular disease. Carotid intima media thickness (cIMT) is frequently used to identify populations at elevated cardiovascular risk. A systematic literature search and meta-analysis were performed to evaluate cIMT difference between RA and controls. Methods: The literature was screened to identify all available studies comparing cIMT in RA patients and controls. Random effects meta-analysis was performed to estimate the overall mean cIMT difference between both groups. Meta-regression was performed to assess the influence of age and the degree of comparability regarding established cardiovascular risk factors on cIMT difference. Potential publication bias was examined by a funnel plot and Egger test. Results: From 22 studies, cIMT data were available from 1384 RA patients and 1147 controls. In 17 of the studies, RA patients had a statistically significantly greater cIMT. The overall mean cIMT difference was 0.09 mm (95%CI: 0.07-0.11 mm). Heterogeneity was observed (I",

author = "{van Sijl}, A.M. and M.J.L. Peters and D.L. Knol and {de Vet}, H.C.W. and M.A. Gonzalez-Gay and Y.M. Smulders and B.A.C. Dijkmans and M.T. Nurmohamed",

year = "2011",

doi = "https://doi.org/10.1016/j.semarthrit.2010.06.006",

language = "English",

volume = "40",

pages = "389--397",

journal = "Seminars in Arthritis and Rheumatism",

issn = "0049-0172",

publisher = "W.B. Saunders Ltd",

number = "5",

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TY - JOUR

T1 - Carotid intima media thickness in rheumatoid arthritis as compared to control subjects: a meta-analysis

AU - van Sijl, A.M.

AU - Peters, M.J.L.

AU - Knol, D.L.

AU - de Vet, H.C.W.

AU - Gonzalez-Gay, M.A.

AU - Smulders, Y.M.

AU - Dijkmans, B.A.C.

AU - Nurmohamed, M.T.

PY - 2011

Y1 - 2011

N2 - Objectives: Rheumatoid arthritis (RA) is associated with increased risk of cardiovascular disease. Carotid intima media thickness (cIMT) is frequently used to identify populations at elevated cardiovascular risk. A systematic literature search and meta-analysis were performed to evaluate cIMT difference between RA and controls. Methods: The literature was screened to identify all available studies comparing cIMT in RA patients and controls. Random effects meta-analysis was performed to estimate the overall mean cIMT difference between both groups. Meta-regression was performed to assess the influence of age and the degree of comparability regarding established cardiovascular risk factors on cIMT difference. Potential publication bias was examined by a funnel plot and Egger test. Results: From 22 studies, cIMT data were available from 1384 RA patients and 1147 controls. In 17 of the studies, RA patients had a statistically significantly greater cIMT. The overall mean cIMT difference was 0.09 mm (95%CI: 0.07-0.11 mm). Heterogeneity was observed (I

AB - Objectives: Rheumatoid arthritis (RA) is associated with increased risk of cardiovascular disease. Carotid intima media thickness (cIMT) is frequently used to identify populations at elevated cardiovascular risk. A systematic literature search and meta-analysis were performed to evaluate cIMT difference between RA and controls. Methods: The literature was screened to identify all available studies comparing cIMT in RA patients and controls. Random effects meta-analysis was performed to estimate the overall mean cIMT difference between both groups. Meta-regression was performed to assess the influence of age and the degree of comparability regarding established cardiovascular risk factors on cIMT difference. Potential publication bias was examined by a funnel plot and Egger test. Results: From 22 studies, cIMT data were available from 1384 RA patients and 1147 controls. In 17 of the studies, RA patients had a statistically significantly greater cIMT. The overall mean cIMT difference was 0.09 mm (95%CI: 0.07-0.11 mm). Heterogeneity was observed (I

U2 - https://doi.org/10.1016/j.semarthrit.2010.06.006

DO - https://doi.org/10.1016/j.semarthrit.2010.06.006

M3 - Article

C2 - 20889191

SN - 0049-0172

VL - 40

SP - 389

EP - 397

JO - Seminars in Arthritis and Rheumatism

JF - Seminars in Arthritis and Rheumatism

IS - 5

ER -